ArticleThe American journal of pathology2004
Fibroblast growth factor enriches the embryonic liver cultures for hepatic progenitors.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Plasticity, heterogeneity, and multifunctionality of hepatic stellate cells in liver pathophysiology.Hepatology communications · 2024Review
- Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation.Science signaling · 2023Article
- PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis.International journal of molecular sciences · 2020Article
- Wnt-β-catenin signalling in liver development, health and disease.Nature reviews. Gastroenterology & hepatology · 2019Review
- Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment.International journal of molecular sciences · 2018Review
- Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes.Cell proliferation · 2015Review
- Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent β-catenin activation.Journal of hepatology · 2014Article
- Role and regulation of β-catenin signaling during physiological liver growth.Gene expression · 2014Review
- Bone marrow cell-based regenerative therapy for liver cirrhosis.World journal of methodology · 2013Review
- The road to regenerative liver therapies: the triumphs, trials and tribulations.Biotechnology advances · 2013Review
- FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.Molecular and cellular endocrinology · 2013Article
- Akt and mTORC1 have different roles during liver tumorigenesis in mice.Gastroenterology · 2013Article
- Hepatic stellate cells in liver development, regeneration, and cancer.The Journal of clinical investigation · 2013Review
- Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish.Transgenic research · 2013Article
- Cellular and molecular basis of liver development.Comprehensive Physiology · 2013Review
- Enhanced differentiation of adult bone marrow-derived stem cells to liver lineage in aggregate culture.Tissue engineering. Part A · 2011Article
- Beta-catenin signaling in hepatic development and progenitors: which way does the WNT blow?Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Article
- β-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis.The Journal of surgical research · 2010Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Fibroblast growth factors (FGFs) play an important role in hepatic induction during development. The aim of our study was to investigate the effect of exogenous FGFs on ex vivo liver development. We begin our analysis by examining FGF signaling during early mouse liver development. Phospho-FGF receptor (Tyr653/654) was detected in embryonic day 10 (E10) to E12 livers only. Next, E10 livers were cultured in the presence of FGF1, FGF4, or FGF8 for 72 hours and examined for histology, proliferation, apoptosis, and differentiation. FGFs especially FGF8 promoted sheet-like architecture, cell proliferation, and survival as compared to the control. All FGFs induced a striking increase in the number of c-kit and alpha-fetoprotein-positive progenitors, without altering albumin staining. However these progenitors were CK-19-positive (biliary and bipotential progenitor marker) only in the presence of FGF1 or FGF4 and not FGF8. FGFs also induced beta-catenin, a stem cell renewal factor in these cultures. In conclusion, the presence of activated FGFR indicates a physiological role of FGF during early liver development. FGF1 and FGF4 enrich the embryonic liver cultures for bipotential hepatic progenitors. FGF8 promotes such enrichment and induces a one-step differentiation toward a unipotential hepatocyte progenitor. Thus, FGFs might be useful for enrichment and propagation of developmental hepatic progenitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.