ArticleInternational journal of legal medicine2004
Different methods to determine length heteroplasmy within the mitochondrial control region.
Article in International journal of legal medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- mtDNA Heteroplasmy: Origin, Detection, Significance, and Evolutionary Consequences.Life (Basel, Switzerland) · 2021Review
- Organization and phylogenetic relationships of the mitochondrial genomes of Speiredonia retorta and other lepidopteran insects.Scientific reports · 2021Article
- Article
- Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity.Nucleic acids research · 2016Article
- Comparative Mitochondrial Genome Analysis of Eligma narcissus and other Lepidopteran Insects Reveals Conserved Mitochondrial Genome Organization and Phylogenetic Relationships.Scientific reports · 2016Article
- Length heteroplasmy of the polyC-polyT-polyC stretch in the dog mtDNA control region.International journal of legal medicine · 2015Article
- Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity.BMC genomics · 2015Article
- The Complete Mitochondrial Genome of the Beet Webworm, Spoladea recurvalis (Lepidoptera: Crambidae) and Its Phylogenetic Implications.PloS one · 2015Article
- Article
- Mass spectrometric base composition profiling: Implications for forensic mtDNA databasing.Forensic science international. Genetics · 2013Article
- Article
- The Complete Mitochondrial Genome of Ctenoptilum vasava (Lepidoptera: Hesperiidae: Pyrginae) and Its Phylogenetic Implication.Comparative and functional genomics · 2012Article
- CHILD: a new tool for detecting low-abundance insertions and deletions in standard sequence traces.Nucleic acids research · 2011Article
- Inspecting close maternal relatedness: Towards better mtDNA population samples in forensic databases.Forensic science international. Genetics · 2011Article
- Evaluating sequence-derived mtDNA length heteroplasmy by amplicon size analysis.Forensic science international. Genetics · 2011Article
- Evaluating length heteroplasmy in the human mitochondrial DNA control region.International journal of legal medicine · 2010Article
- Sequence-length variation of mtDNA HVS-I C-stretch in Chinese ethnic groups.Journal of Zhejiang University. Science. B · 2009Article
- Investigation of heteroplasmy in the human mitochondrial DNA control region: a synthesis of observations from more than 5000 global population samples.Journal of molecular evolution · 2009Article
- Analysis of mitochondrial length heteroplasmy in monozygous and non-monozygous siblings.International journal of legal medicine · 2008Article
- Liquid chromatography-electrospray ionization mass spectrometry for simultaneous detection of mtDNA length and nucleotide polymorphisms.International journal of legal medicine · 2007Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first and second hypervariable regions of the human mitochondrial DNA control region contain two homopolymeric stretches of cytosine (nt 16184-16193 and nt303-315, respectively). According to the Cambridge reference sequence these homopolymeric stretches are interrupted by thymine (T), at positions 16189 and 310, respectively. Monotonous runs of the same base have been suggested to be hot spots for mutations, probably caused by replication slippage, resulting in length heteroplasmy. This paper describes a rapid method based on restriction cleavage of labelled PCR products encompassing the homopolymeric tract in HVII to quantify the relative proportions of different length variants present in an individual. To compare the accuracy of this method, cloned PCR products from several heteroplasmic individuals have been additionally sequenced.
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