Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2004
Echinacea purpurea for prevention of experimental rhinovirus colds.
Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review.Nutrients · 2022Pooled it
- Echinacea for preventing and treating the common cold.The Cochrane database of systematic reviews · 2014Pooled it
- Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis.The Lancet. Infectious diseases · 2007Pooled it
- Echinacea for treating the common cold: a randomized trial.Annals of internal medicine · 2010Trial
- Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial.European journal of medical research · 2009Trial
- Effects of echinacea on the frequency of upper respiratory tract symptoms: a randomized, double-blind, placebo-controlled trial.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2008Trial
- Phytochemistry, Mechanisms, and Preclinical Studies of Echinacea Extracts in Modulating Immune Responses to Bacterial and Viral Infections: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2024Review
- Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA).Antibiotics (Basel, Switzerland) · 2024Review
- A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy.Life (Basel, Switzerland) · 2022Review
- The effect ofAdvances in integrative medicine · 2020Article
- Evidence map on the contributions of traditional, complementary and integrative medicines for health care in times of COVID-19.Integrative medicine research · 2020Review
- Update on Human Rhinovirus and Coronavirus Infections.Seminars in respiratory and critical care medicine · 2016Review
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
- Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?Frontiers in pharmacology · 2014Review
- Human rhinoviruses.Clinical microbiology reviews · 2013Review
- Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Echinacea tennesseensis ethanol tinctures harbor cytokine- and proliferation-enhancing capacities.Cytokine · 2009Article
- Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells.BMC genomics · 2008Article
- Echinacea species and alkamides inhibit prostaglandin E(2) production in RAW264.7 mouse macrophage cells.Journal of agricultural and food chemistry · 2007Article
- Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension.Journal of AOAC InternationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the ability of Echinacea purpurea to prevent infection with rhinovirus type 39 (RV-39). Forty-eight previously healthy adults received echinacea or placebo, 2.5 mL 3 times per day, for 7 days before and 7 days after intranasal inoculation with RV-39. Symptoms were assessed to evaluate clinical illness. Viral culture and serologic studies were performed to evaluate the presence of rhinovirus infection. A total of 92% of echinacea recipients and 95% of placebo recipients were infected. Colds developed in 58% of echinacea recipients and 82% of placebo recipients (P=.114, by Fisher's exact test). Administration of echinacea before and after exposure to rhinovirus did not decrease the rate of infection; however, because of the small sample size, statistical hypothesis testing had relatively poor power to detect statistically significant differences in the frequency and severity of illness.
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