ReviewFunctional & integrative genomics2004
Activation tagging in plants: a tool for gene discovery.
Review in Functional & integrative genomics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Review
- Gain-of-function mutagenesis through activation tagging identifies XPB2 and SEN1 helicase genes as potential targets for drought stress tolerance in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- A partial T-DNA insertion nearmicroPublication biology · 2020Article
- Constructing the bundle sheath towards enhanced photosynthesis.Journal of experimental botany · 2020Article
- Targeted misexpression of NAC052, acting in H3K4 demethylation, alters leaf morphological and anatomical traits in Arabidopsis thaliana.Journal of experimental botany · 2020Article
- Activation-tagging in indica rice identifies a novel transcription factor subunit, NF-YC13 associated with salt tolerance.Scientific reports · 2017Article
- Comparison of the impact of viral and plant-derived promoters regulating selectable marker gene on maize transformation and transgene expression.Plant cell reports · 2017Article
- Arabidopsis Qc-SNARE gene AtSFT12 is involved in salt and osmotic stress responses and Na(+) accumulation in vacuoles.Plant cell reports · 2015Article
- The Arabidopsis chloroplast protein S-RBP11 is involved in oxidative and salt stress responses.Plant cell reports · 2014Article
- Application of T-DNA activation tagging to identify glutamate receptor-like genes that enhance drought tolerance in plants.Plant cell reports · 2014Article
- POLYGALACTURONASE INVOLVED IN EXPANSION1 functions in cell elongation and flower development in Arabidopsis.The Plant cell · 2014Article
- Activation tagging in Salvia miltiorrhiza can cause increased leaf size and accumulation of tanshinone I and IIA in its roots.Botanical studies · 2013Article
- Ac/Ds-transposon activation tagging in poplar: a powerful tool for gene discovery.BMC genomics · 2012Article
- Perspectives on Systematic Analyses of Gene Function in Arabidopsis thaliana: New Tools, Topics and Trends.Current genomics · 2011Article
- Article
- An archived activation tagged population of Arabidopsis thaliana to facilitate forward genetics approaches.BMC plant biology · 2009Article
- Phenome analysis in plant species using loss-of-function and gain-of-function mutants.Plant & cell physiology · 2009Review
- A barley activation tagging system.Plant molecular biology · 2007Article
- Isolation and molecular characterization of a Spotted leaf 18 mutant by modified activation-tagging in rice.Plant molecular biology · 2007Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
A significant limitation of classical loss-of-function screens designed to dissect genetic pathways is that they rarely uncover genes that function redundantly, are compensated by alternative metabolic or regulatory circuits, or which have an additional role in early embryo or gametophyte development. Activation T-DNA tagging is one approach that has emerged in plants to help circumvent these potential problems. This technique utilises a T-DNA sequence that contains four tandem copies of the cauliflower mosaic virus (CaMV) 35S enhancer sequence. This element enhances the expression of neighbouring genes either side of the randomly integrated T-DNA tag, resulting in gain-of-function phenotypes. Activation tagging has identified a number of genes fundamental to plant development, metabolism and disease resistance in Arabidopsis. This review provides selected examples of these discoveries to highlight the utility of this technology. The recent development of activation tagging strategies for other model plant systems and the construction of new more sophisticated vectors for the generation of conditional alleles are also discussed. These recent advances have significantly expanded the horizons for gain-of-function genetics in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.