ArticleProceedings of the National Academy of Sciences of the United States of America2004
Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 110 citations in OpenAlex.
- Engineered microtissue systems for identifying the roles of Wnt and YAP signaling in hepatoblast differentiation and organization.Materials today. Bio · 2026Article
- Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma.eLife · 2023Article
- Microtissue Geometry and Cell-Generated Forces Drive Patterning of Liver Progenitor Cell Differentiation in 3D.Advanced healthcare materials · 2021Article
- Utility of Common Marmoset (Genes · 2020Review
- Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis.Gene expression · 2020Article
- Integration of Hydrogel Microparticles With Three-Dimensional Liver Progenitor Cell Spheroids.Frontiers in bioengineering and biotechnology · 2020Article
- Article
- [Clinical significance and correlation of ductular reaction in hepatobiliary diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018Article
- [Research advances in the role of the Hippo signaling pathway in pathogenesis of liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017Article
- Combinatorial microenvironmental regulation of liver progenitor differentiation by Notch ligands, TGFβ, and extracellular matrix.Scientific reports · 2016Article
- A Transcriptomic Signature of Mouse Liver Progenitor Cells.Stem cells international · 2016Article
- Orchestrating liver development.Development (Cambridge, England) · 2015Review
- Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury.PloS one · 2015Article
- Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice.Stem cells international · 2015Article
- New insights in hepatocellular carcinoma: from bench to bedside.Annals of translational medicine · 2013Review
- Ontogenesis of hepatic and pancreatic stem cells.Stem cell reviews and reports · 2012Review
- Culture of porcine hepatocytes or bile duct epithelial cells by inductive serum-free media.In vitro cellular & developmental biology. Animal · 2011Article
- Facultative stem cells in liver and pancreas: fact and fancy.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.The international journal of biochemistry & cell biology · 2011Review
- Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation.Genome research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cell lines have many advantages: they can be manipulated genetically, expanded, and stockpiled for organ transplantation. Freshly isolated hepatocytes, oval cells, pancreatic cells, and hematopoietic stem cells have been shown to repopulate the damaged liver. Here we show that bipotential mouse embryonic liver (BMEL) stem cell lines participate in liver regeneration in albumin-urokinase plasminogen activator/severe combined immunodeficiency disease (Alb-uPA/SCID) transgenic mice. In the liver, BMEL-GFP cells proliferate and differentiate into both hepatocytes and bile ducts, forming small to large clusters detected throughout the 3-8 weeks analyzed after transplantation. Moreover, they respond like host cells to signals for growth, differentiation, and even zonal expression of metabolic enzymes, showing regulated expression of cytokeratins and liver-enriched transcription factors. Immunostaining for MHC class I molecules revealed that cells do not coexpress donor and recipient H-2 haplotypes, as would be the case had cell fusion occurred. This report shows that immortalized stem cell lines not only are competent to participate in the repair of a damaged tissue but also can differentiate into the two major epithelial cell types of a complex organ, hepatocytes and bile ducts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.