ArticleInfection and immunity2004
CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Synthetic CpG-ODN rapidly enriches immune compartments in neonatal chicks to induce protective immunity against bacterial infections.Scientific reports · 2019Article
- Effect of Calcium Carbonate Encapsulation on the Activity of Orally Administered CpG Oligonucleotides.Molecular therapy. Nucleic acids · 2017Article
- Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats.American journal of physiology. Heart and circulatory physiology · 2016Article
- Preconditioning with intravenous colitic cell-free DNA prevents DSS-colitis by altering TLR9-associated gene expression profile.Digestive diseases and sciences · 2014Article
- From mice to women: the conundrum of immunity to infection during pregnancy.Journal of reproductive immunology · 2013Review
- Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status.TheScientificWorldJournal · 2013Article
- Animal models of listeriosis: a comparative review of the current state of the art and lessons learned.Veterinary research · 2012Review
- TLR-based immune adjuvants.Vaccine · 2011Review
- Short- and long-term changes in gene expression mediated by the activation of TLR9.Molecular immunology · 2010Article
- The Key Events Dose-Response Framework: its potential for application to foodborne pathogenic microorganisms.Critical reviews in food science and nutrition · 2009Article
- TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Tweaking Innate Immunity: the Promise of Innate Immunologicals As Anti-infectives.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2006Article
- Contribution of nitric oxide to CpG-mediated protection against Listeria monocytogenes.Infection and immunity · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of healthy adult mice to many infectious pathogens, including Listeria monocytogenes. This study examines whether the innate immune response elicited by CpG ODN can reduce the susceptibility of pregnant mice to lethal listeria challenge. The results indicate that CpG ODN treatment significantly improves maternal survival and reduces pathogen transmission to offspring. CpG ODN administered during pregnancy did not induce abortion, birth defects, or reduce the size or health of litters. These findings suggest that CpG ODN may provide a safe and effective means of improving the health of mothers and fetuses during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.