ArticleInfection and immunity2004
Disassembly of F-actin cytoskeleton after interaction of Bacillus cereus with fully differentiated human intestinal Caco-2 cells.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Pathogenesis of human-derivedFrontiers in cellular and infection microbiology · 2026Article
- The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes toVirulence · 2020Article
- Porcine Gastric Mucin Triggers Toxin Production of EnteropathogenicInfection and immunity · 2019Article
- Consumed Foodstuffs Have a Crucial Impact on the Toxic Activity of EnteropathogenicFrontiers in microbiology · 2018Article
- Article
- Pathogenic potential of Bacillus cereus strains as revealed by phenotypic analysis.Journal of clinical microbiology · 2013Article
- Expanding the known repertoire of virulence factors produced by Bacillus cereus through early secretome profiling in three redox conditions.Molecular & cellular proteomics : MCP · 2010Article
- CwpFM (EntFM) is a Bacillus cereus potential cell wall peptidase implicated in adhesion, biofilm formation, and virulence.Journal of bacteriology · 2010Article
- Bacillus cereus-induced permeability of the blood-ocular barrier during experimental endophthalmitis.Investigative ophthalmology & visual science · 2009Article
- Bacillus cereus induces permeability of an in vitro blood-retina barrier.Infection and immunity · 2008Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, the role of direct procaryote-eucaryote interactions in the virulence of Bacillus cereus was investigated. As a model of human enterocytes, differentiated Caco-2 cells were used. Infection of fully differentiated Caco-2 cells with B. cereus in the exponential phase of growth, in order to minimize the concentration of spores or sporulating microorganisms, shows that a strain-dependent cytopathic effect develops. Interestingly, addition of 3-h-old cultures of some strains resulted in complete detachment of the cultured cells after a 3-h infection whereas no such effect was found after a 3-h infection with 16-h-old cultures. Infection of enterocyte-like cells with B. cereus leads to disruption of the F-actin network and necrosis. Even though the effect of secreted factors cannot be ruled out, direct eucaryote-procaryote interaction seems to be necessary. In addition, we observed that some B. cereus strains were able to be internalized in Caco-2 cells. Our findings add a new insight into the mechanisms of virulence of B. cereus in the context of intestinal infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.