ArticleBritish journal of sports medicine2004
Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department.
Article in British journal of sports medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Muscle and intestinal damage in triathletes.PloS one · 2019Trial
- Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.The New England journal of medicine · 2011Trial
- Exercise-induced changes in hemostasis markers in marathon runners: effects of enzyme supplementation and determinants.Frontiers in physiology · 2026Article
- Circuit resistance training and Zataria Multiflora: a dual approach to improving blood rheology in postmenopausal women.Journal of diabetes and metabolic disorders · 2025Article
- The Impact of Endurance Exercise on Routine Laboratory Parameters in Young Trained Individuals.Journal of clinical medicine · 2025Article
- Adrenal steroid hormone responses to exercise under thermal stress: Potential role for nonclassic congenital adrenal hyperplasia in heat illness susceptibility.Physiological reports · 2025Article
- IBS008738, a TAZ activator, facilitates muscle repair and inhibits muscle injury in a mouse model of sport-induced injury.Cytotechnology · 2025Article
- Physiology and Pathophysiology of Marathon Running: A narrative Review.Sports medicine - open · 2025Review
- Changes in Skeletal Muscle Troponin T and Vitamin D Binding Protein (DBP) Concentrations in the Blood of Male Amateur Athletes Participating in a Marathon and 100 km Adventure Race.International journal of environmental research and public health · 2023Article
- Cardiac Biomarkers in Sports Cardiology.Journal of cardiovascular development and disease · 2022Review
- Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Four Weeks of Probiotic Supplementation Alters the Metabolic Perturbations Induced by Marathon Running: Insight from Metabolomics.Metabolites · 2021Article
- Remote Ischemic Preconditioning Reduces Marathon-Induced Oxidative Stress and Decreases Liver and Heart Injury Markers in the Serum.Frontiers in physiology · 2021Article
- Effects of Oral Branched-Chain Amino Acids (BCAAs) Intake on Muscular and Central Fatigue During an Incremental Exercise.Journal of human kinetics · 2020Article
- Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance.Heliyon · 2019Article
- The Oxidative Stress Response in Elite Water Polo Players: Effects of Genetic Background.BioMed research international · 2017Article
- The Effect of a 100-km Ultra-Marathon under Freezing Conditions on Selected Immunological and Hematological Parameters.Frontiers in physiology · 2017Article
- Investigating the Cellular and Metabolic Responses of World-Class Canoeists Training: A Sportomics Approach.Nutrients · 2016Article
- Observational
- Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The "Study of Origin".BioMed research international · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the effects of strenuous exercise on commonly used biochemical and haematological variables in subjects running the 2002 London marathon.
methods34 healthy volunteers (7 female, 27 male) were recruited for the study. Blood was taken before the start (at registration) and immediately after completion of the marathon. Samples were analysed for urea and electrolytes, liver function tests, creatine kinase (CK), CK-MB isoenzyme, myoglobin, troponin I, full blood count, a clotting screen, and D-dimers. The results before and after exercise were compared. Pearson's correlation coefficients were calculated for all variables.
resultsSignificant increases were found in CK, CK-MB, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and myoglobin following the marathon. However, there was no significant change in the level of troponin I. There was also evidence of activation of the coagulation and fibrinolytic cascades following the marathon, with a reduction in activated partial thromboplastin time, a reduction in fibrinogen, and an increase in D-dimers.
conclusionsThe results confirm previous individual studies on marathon running and the biochemical and haematological tests routinely carried out in hospital. These are affected by prolonged exercise, and "abnormal" results in these tests may be normal after prolonged exercise and therefore not diagnostic of a disease process. The results of investigations in patients who have been exercising should be interpreted with caution.
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