Evidence map›Paper›PMID 15155236›Full record

ArticleAntimicrobial agents and chemotherapy2004

Posaconazole therapy of disseminated phaeohyphomycosis in a murine model.

John R Graybill, Laura K Najvar, Elizabeth Johnson, Rosie Bocanegra, David Loebenberg

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 42 citations in OpenAlex.

  1. Experimental Infection of Mice withComparative medicine · 2019
    Article
  2. CNS Infections Caused by Brown-Black Fungi.Journal of fungi (Basel, Switzerland) · 2019
    Review
  3. Review
  4. Article
  5. Mycetoma medical therapy.PLoS neglected tropical diseases · 2014
    Review
  6. Review
  7. Article
  8. What can we learn and what do we need to know amidst the iatrogenic outbreak of Exserohilum rostratum meningitis?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013
    Article
  9. Reflections on the approach to treatment of a mycologic disaster.Antimicrobial agents and chemotherapy · 2013
    Article
  10. Article
  11. Article
  12. Melanized fungi in human disease.Clinical microbiology reviews · 2010
    Review
  13. Article
  14. Article
  15. Posaconazole.Drugs · 2005
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

John R GraybillDepartment of Medicine, Division of Infectious Diseases, Medicine/ID Mail Code 7881, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA.
Laura K Najvar
Elizabeth Johnson
Rosie Bocanegra
David Loebenberg
The University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunocompetent (nu/+) and athymic (nu/nu) BALB/c mice were infected intravenously with Wangiella dermatitidis and treated with posaconazole. Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain.

Indexed as

ExophialaAnimalsAntifungal AgentsBrainColony Count, MicrobialImmunocompromised HostMiceMice, Inbred BALB CMice, NudeMycosesSurvival AnalysisTriazolesAntifungal AgentsposaconazoleTriazoles

Identifiers

PMID15155236
PMCPMC415573
OpenAlexW2145845874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.