ArticleAntimicrobial agents and chemotherapy2004
Genetic environments of the rmtA gene in Pseudomonas aeruginosa clinical isolates.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens.Antimicrobial agents and chemotherapy · 2025Article
- Phenotypic and genotypic assessment of fluoroquinolones and aminoglycosides resistances in Pseudomonas aeruginosa collected from Minia hospitals, Egypt during COVID-19 pandemic.BMC infectious diseases · 2024Article
- Prevalence of Aminoglycoside Resistance Genes in Clinical Isolates ofMicroorganisms · 2023Article
- Research Updates of Plasmid-Mediated Aminoglycoside Resistance 16S rRNA Methyltransferase.Antibiotics (Basel, Switzerland) · 2022Review
- Antimicrobial Resistance and Transconjugants Characteristics ofAnimals : an open access journal from MDPI · 2022Article
- Aminoglycoside Resistance: Updates with a Focus on Acquired 16S Ribosomal RNA Methyltransferases.Infectious disease clinics of North America · 2020Review
- Emergence of antibiotic resistanceGenes & diseases · 2019Review
- How to manageDrugs in context · 2018Review
- Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases.Infectious disease clinics of North America · 2016Review
- Molecular epidemiology of aminoglycosides resistance on Klebsiella pneumonia in a hospital in China.International journal of clinical and experimental medicine · 2015Article
- Pseudomonas aeruginosa: resistance to the max.Frontiers in microbiology · 2011Article
- Discovery of a gene conferring multiple-aminoglycoside resistance in Escherichia coli.Antimicrobial agents and chemotherapy · 2010Article
- Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms.Clinical microbiology reviews · 2009Review
- Abstracts of the 19th ECCMID (European Congress of Clinical Microbiology and Infectious Diseases). Helsinki, Finland. May 16-19, 2009.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2009Article
- Plasmid-mediated 16S rRNA methylases in aminoglycoside-resistant Enterobacteriaceae isolates in Shanghai, China.Antimicrobial agents and chemotherapy · 2009Article
- Genetic environment of 16S rRNA methylase gene rmtD.Antimicrobial agents and chemotherapy · 2008Article
- RmtC 16S rRNA methyltransferase in Australia.Antimicrobial agents and chemotherapy · 2008Article
- Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.Antimicrobial agents and chemotherapy · 2007Article
- 16S rRNA methylase-producing, gram-negative pathogens, Japan.Emerging infectious diseases · 2007Article
- Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.Antimicrobial agents and chemotherapy · 2007Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nine Pseudomonas aeruginosa strains showing very high levels of resistance to various aminoglycosides have been isolated from clinical specimens in seven separate Japanese hospitals in five prefectures since 1997. These strains harbor the newly identified 16S rRNA methylase gene (rmtA). When an rmtA gene probe was hybridized with genomic DNAs of the nine strains digested with EcoRI, two distinct patterns were observed. The 11.1- and 15.8-kb regions containing the rmtA genes of strains AR-2 and AR-11, respectively, were sequenced and compared. In strain AR-2, a transposase gene-like sequence (sequence 1) and a probable tRNA ribosyltransferase gene (orfA) were located upstream of rmtA, and a Na(+)/H(+) antiporter gene-like sequence (sequence 2) was identified downstream of rmtA. This 6.2-kbp insert (the rmtA locus) was flanked by 262-bp kappagamma elements. Part of the orfQ gene adjacent to an inverted repeat was found outside of the rmtA locus. In strain AR-11, the rmtA gene and sequence 2 were found, but the 5' end of the orfA gene was truncated and replaced with IS6100. An orfQ-orfI region was present on each side of the rmtA gene in strain AR-11. The G+C content of the rmtA gene was about 55%, and since the newly identified rmtA gene may well be mediated by some mobile genetic elements such as Tn5041, further dissemination of the rmtA gene could become an actual clinical problem in the near future.
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