ArticleAntimicrobial agents and chemotherapy2004
Tn2009, a Tn916-like element containing mef(E) in Streptococcus pneumoniae.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Large-scale global molecular epidemiology of antibiotic resistance determinants inMicrobial genomics · 2025Article
- Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2024Article
- The Crisis of Macrolide Resistance in Pneumococci in Latin America.The American journal of tropical medicine and hygiene · 2024Review
- TheJournal of bacteriology · 2023Article
- Regulation of the macrolide resistance ABC-F translation factor MsrD.Nature communications · 2023Article
- Characterization and Fitness Cost of TnFrontiers in microbiology · 2022Article
- Predicted transmembrane proteins with homology to Mef(A) are not responsible for complementing mef(A) deletion in the mef(A)-msr(D) macrolide efflux system in Streptococcus pneumoniae.BMC research notes · 2021Article
- Prevalence, diversity and transferability of the TnJournal of oral microbiology · 2021Article
- Penicillin-Binding Protein Typing, Antibiotic Resistance Gene Identification, and Molecular Phylogenetic Analysis of Meropenem-Resistant Streptococcus pneumoniae Serotype 19A-CC3111 Strains in Japan.Antimicrobial agents and chemotherapy · 2019Article
- High-Level Macrolide Resistance Due to the Mega Element [Frontiers in microbiology · 2019Article
- Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily.Frontiers in microbiology · 2018Article
- Antibiotic Resistance Patterns and Related Mobile Genetic Elements of Pneumococci and β-Hemolytic Streptococci in Thai Healthy Children.Indian journal of microbiology · 2016Article
- Resistance to Macrolide Antibiotics in Public Health Pathogens.Cold Spring Harbor perspectives in medicine · 2016Review
- ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes.Antimicrobial agents and chemotherapy · 2016Article
- Macrolide Resistance inFrontiers in cellular and infection microbiology · 2016Review
- Whole-genome Sequencing for Surveillance of Invasive Pneumococcal Diseases in Ontario, Canada: Rapid Prediction of Genotype, Antibiotic Resistance and Characterization of Emerging Serotype 22F.Frontiers in microbiology · 2016Article
- Composite mobile genetic elements disseminating macrolide resistance in Streptococcus pneumoniae.Frontiers in microbiology · 2015Article
- Variation on a theme; an overview of the Tn916/Tn1545 family of mobile genetic elements in the oral and nasopharyngeal streptococci.Frontiers in microbiology · 2014Review
- Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974.BMC genomics · 2013Article
- Developing insights into the mechanisms of evolution of bacterial pathogens from whole-genome sequences.Future microbiology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between the macrolide efflux gene mef(E) and the tet(M) gene was studied in two clinical strains of Streptococcus pneumoniae that belonged to serotypes 19F and 6A, respectively, and that were resistant to both tetracycline and erythromycin. The mef(E)-carrying element mega (macrolide efflux genetic assembly; 5,511 bp) was found to be inserted into a Tn916-like genetic element present in the chromosomes of the two pneumococcal strains. In both strains, mega was integrated at the same site, an open reading frame identical to orf6 of Tn916. The new composite element, Tn2009, was about 23.5 kb and, with the exception of the tet(M)-coding sequence, appeared to be identical in both strains. By sequencing of the junction fragments of Tn2009 at the site of insertion into the chromosome, it was possible to show that (i) the insertion site was identical in the two clinical strains and (ii) the integration of Tn2009 caused a 9.5 kb-deletion in the pneumococcal chromosome. It was not possible to detect the conjugal transfer of Tn2009 to a recipient pneumococcal strain; however, transfer of the whole element by transformation was shown to occur. It is possible to hypothesize that Tn2009 relies on transformation for its spread among clinical strains of S. pneumoniae.
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