ArticleAntimicrobial agents and chemotherapy2004
Susceptibility of Candida species to photodynamic effects of photofrin.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 150 citations in OpenAlex.
- Photodynamic inactivation of microorganisms present on complete dentures. A clinical investigation. Photodynamic disinfection of complete dentures.Lasers in medical science · 2012Trial
- Efficiency of the photodynamic therapy on viability of Streptococcus mutans in the oral cavity using chitosan nanoparticles: an in vitro study.Lasers in medical science · 2024Article
- Combined bisdemethoxycurcumin and potassium iodide-mediated antimicrobial photodynamic therapy.Heliyon · 2023Article
- Photoinactivation of Planktonic Cells, Pseudohyphae, and Biofilms ofAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Phototherapy and optical waveguides for the treatment of infection.Advanced drug delivery reviews · 2021Review
- Effectiveness of antimicrobial photodynamic therapy with indocyanine green against the standard and fluconazole-resistant Candida albicans.Lasers in medical science · 2021Article
- Photosensitizers Mediated Photodynamic Inactivation against Fungi.Nanomaterials (Basel, Switzerland) · 2021Review
- Sensitivity of Four Various Candida Species to Photodynamic Therapy Mediated by Indocyanine Green, an in vitro Study.Journal of dentistry (Shiraz, Iran) · 2021Article
- Utility of Photodynamic Therapy in Dentistry: Current Concepts.Dentistry journal · 2020Review
- Photodynamic Inactivation ofAntibiotics (Basel, Switzerland) · 2019Article
- Advancing antimicrobial strategies for managing oral biofilm infections.International journal of oral science · 2019Review
- Twice-daily red and blue light treatment for Candida albicans biofilm matrix development control.Lasers in medical science · 2019Article
- Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei.Lasers in medical science · 2018Article
- Advances in antimicrobial photodynamic inactivation at the nanoscale.Nanophotonics (Berlin, Germany) · 2017Article
- Virulence factors of fluconazole-susceptible and fluconazole-resistant Candida albicans after antimicrobial photodynamic therapy.Lasers in medical science · 2017Article
- Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings.Molecules (Basel, Switzerland) · 2017Article
- Assessment of Photodynamic Inactivation against Periodontal Bacteria Mediated by a Chitosan Hydrogel in a 3D Gingival Model.International journal of molecular sciences · 2016Article
- Photodynamic inactivation of a multispecies biofilm using curcumin and LED light.Lasers in medical science · 2016Article
- Methylene Blue-Loaded Dissolving Microneedles: Potential Use in Photodynamic Antimicrobial Chemotherapy of Infected Wounds.Pharmaceutics · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The in vitro susceptibility of pathogenic Candida species to the photodynamic effects of the clinically approved photosensitizing agent Photofrin was examined. Internalization of Photofrin by Candida was confirmed by confocal fluorescence microscopy, and the degree of uptake was dependent on incubation concentration. Uptake of Photofrin by Candida and subsequent sensitivity to irradiation was influenced by culture conditions. Photofrin uptake was poor in C. albicans blastoconidia grown in nutrient broth. However, conversion of blastoconidia to filamentous forms by incubation in defined tissue culture medium resulted in substantial Photofrin uptake. Under conditions where Photofrin was effectively taken up by Candida, irradiated organisms were damaged in a drug dose- and light-dependent manner. Uptake of Photofrin was not inhibited by azide, indicating that the mechanism of uptake was not dependent on energy provided via electron transport. Fungal damage induced by Photofrin-mediated photodynamic therapy (PDT) was determined by evaluation of metabolic activity after irradiation. A strain of C. glabrata took up Photofrin poorly and was resistant to killing after irradiation. In contrast, two different strains of C. albicans displayed comparable levels of sensitivity to PDT. Furthermore, a reference strain of C. krusei that is relatively resistant to fluconazole compared to C. albicans was equally sensitive to C. albicans at Photofrin concentrations of >/=3 microg/ml. The results indicate that photodynamic therapy may be a useful adjunct or alternative to current anti-Candida therapeutic modalities, particularly for superficial infections on surfaces amenable to illumination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.