ArticleAntimicrobial agents and chemotherapy2004
Reactivity of platelia Aspergillus galactomannan antigen with piperacillin-tazobactam: clinical implications based on achievable concentrations in serum.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00386802 (ANTIVORIFUNGOL), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ANTIVORIFUNGOL:Strategy of Antifungal Use in Oncohematological Neutropenic Patients. Use of Voriconazole as Early Treatment.
Who cites it
15 citing papers in PubMed, 84 citations in OpenAlex.
- In Vitro Anti-Journal of fungi (Basel, Switzerland) · 2026Article
- Generic piperacillin/tazobactam is not associated with galactomannan false-positivity in adult patients with cancer: a case-control study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Cross-reactivity of Aspergillus galactomannan in an HIV-infected patient with histoplasmosis.Medical mycology case reports · 2012Article
- Pulmonary aspergillosis: a clinical review.European respiratory review : an official journal of the European Respiratory Society · 2011Review
- Cross-reactivity of Paracoccidioides brasiliensis, Histoplasma capsulatum, and Cryptococcus species in the commercial Platelia Aspergillus enzyme immunoassay.Clinical and vaccine immunology : CVI · 2009Article
- Galactomannan antigenemia in pediatric oncology patients with invasive aspergillosis.The Pediatric infectious disease journal · 2008Article
- Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis.Mycopathologia · 2007Review
- Occurrence and kinetics of false-positive Aspergillus galactomannan test results following treatment with beta-lactam antibiotics in patients with hematological disorders.Journal of clinical microbiology · 2006Article
- Evaluation of a (1->3)-beta-D-glucan assay for diagnosis of invasive fungal infections.Journal of clinical microbiology · 2005Article
- Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate.Clinical and diagnostic laboratory immunology · 2005Article
- Detection of Aspergillus galactomannan antigenemia to determine biological and clinical implications of beta-lactam treatments.Journal of clinical microbiology · 2005Article
- Galactomannan in piperacillin-tazobactam: how much and to what extent?Antimicrobial agents and chemotherapy · 2005Article
- Aspergillus infections in transplant recipients.Clinical microbiology reviews · 2005Review
- False-positive Aspergillus galactomannan enzyme-linked immunosorbent assay results in vivo during amoxicillin-clavulanic acid treatment.Journal of clinical microbiology · 2004Article
- Drug-laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The possible reactivities of commonly used antibiotics of fungal, nonfungal, and nonmicrobial or synthetic sources with the Platelia Aspergillus galactomannan assay were assessed. For drugs that tested positive, the minimal concentration of the antibiotic in serum that yielded a positive test (index, >0.5) was determined. At undiluted concentrations, piperacillin and multiple lots of piperacillin-tazobactam tested positive, whereas amoxicillin, ampicillin-sulbactam, nafcillin, cefazolin, ceftazidime, erythromycin, gentamicin, and levofloxacin tested negative. All three lots of piperacillin-tazobactam and all bags within each lot tested positive, with a mean index value of 5.168. At achievable concentrations in serum, however, only one of three lots of piperacillin-tazobactam yielded a positive test. Concentrations of 75, 150, and 300 microg/ml of serum tested positive with the Platelia Aspergillus enzyme immunoassay, whereas lower concentrations, mimicking the trough levels, tested negative. Thus, while achievable serum piperacillin-tazobactam concentrations may potentially result in a positive test for galactomannan, the timing of the collection of serum samples from patients may influence the test results, with reactivity being less likely in samples collected at trough levels or prior to the administration of a dose of the antibiotic.
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Registered trials
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