ArticleEMBO reports2004
Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity.
Article in EMBO reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 122 citations in OpenAlex.
- Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation.Neural regeneration research · 2022Article
- Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond.Frontiers in cell and developmental biology · 2020Review
- PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis.Cell death discovery · 2018Article
- Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies.British journal of pharmacology · 2012Review
- Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.The Journal of biological chemistry · 2012Article
- The PIDDosome, DNA-damage-induced apoptosis and beyond.Cell death and differentiation · 2012Review
- Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms.Apoptosis : an international journal on programmed cell death · 2011Article
- A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.Molecular and cellular biology · 2011Article
- Article
- Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells.Toxicology letters · 2010Article
- Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia.Biochimica et biophysica acta · 2010Review
- Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain.The American journal of pathology · 2009Article
- Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism.Cell cycle (Georgetown, Tex.) · 2009Article
- Hepatitis C virus core protein and cellular protein HAX-1 promote 5-fluorouracil-mediated hepatocyte growth inhibition.Journal of virology · 2009Article
- Caspase-2 activation in the absence of PIDDosome formation.The Journal of cell biology · 2009Article
- Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.Cancer science · 2009Article
- The enigma of caspase-2: the laymen's view.Cell death and differentiation · 2009Review
- The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism by which caspase-2 executes apoptosis remains obscure. Recent findings indicate that caspase-2 is activated early in response to DNA-damaging antineoplastic agents and may be important for the engagement of the mitochondrial apoptotic pathway. We demonstrate here that fully processed caspase-2 stimulates mitochondrial release of cytochrome c and Smac/DIABLO, but not apoptosis-inducing factor (AIF). This event occurs independently of several Bcl-2 family proteins, including Bax, Bak and Bcl-2, and inactivation experiments reveal that the proteolytic activity of caspase-2 is not required for the effect. Further, functional studies of mitochondria indicate that processed caspase-2 stimulates state 4 respiration and decreases the respiratory control ratio as a result of, in large part, an uncoupling effect. Combined, our data suggest that caspase-2 retains a unique ability to engage directly the mitochondrial apoptotic pathway, an effect that requires processing of the zymogen but not the associated catalytic activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.