ReviewCritical care (London, England)2004
Bench-to-bedside review: understanding genetic predisposition to sepsis.
Review in Critical care (London, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis.Critical care (London, England) · 2015Pooled it
- Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Trial
- Genomic and integrative based progression biomarker discovery in adult sepsis: toward clinical stratification and precision medicine.Annals of intensive care · 2026Review
- Association ofInternational journal of molecular sciences · 2025Article
- Identifying sepsis susceptibility genes in post-surgical patients using an artificial intelligence approach.Frontiers in medicine · 2025Article
- Review
- Risk Factors for Maternal Readmission with Sepsis.American journal of perinatology · 2020Article
- Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort.Frontiers in genetics · 2020Article
- Ex vivo modelling of the formation of inflammatory platelet-leucocyte aggregates and their adhesion on endothelial cells, an early event in sepsis.Clinical and experimental medicine · 2019Article
- Biomarkers of immune capacity, infection and inflammation are associated with poor outcome and mortality after stroke - the PREDICT study.BMC neurology · 2019Article
- Prognostic Value of MMP-9 -1562 C/T Gene Polymorphism in Patients With Sepsis.Biomarker insights · 2019Article
- Readmissions for Recurrent Sepsis: New or Relapsed Infection?Critical care medicine · 2017Article
- Melanocortin-1 Receptor Polymorphisms and the Risk of Complicated Sepsis After Trauma: A Candidate Gene Association Study.Shock (Augusta, Ga.) · 2017Article
- Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.Clinical and experimental immunology · 2015Article
- Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection.Journal of neuroinflammation · 2015Article
- Assessing the quality of studies supporting genetic susceptibility and outcomes of ARDS.Frontiers in genetics · 2014Article
- Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients.Intensive care medicine · 2013Article
- Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
- Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury.American journal of respiratory cell and molecular biology · 2011Article
- Management and outcome of colorectal anastomotic leaks.International journal of colorectal disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a complex syndrome that develops when the initial, appropriate host response to an infection becomes amplified, and is then dysregulated. Among other factors, the innate immune system is of central importance to the early containment of infection. Death from infection is strongly heritable in human populations. Hence, genetic variations that disrupt innate immune sensing of infectious organisms could explain the ability of the immune system to respond to infection, the diversity of the clinical presentation of sepsis, the response to current medical treatment, and the genetic predisposition to infection in each individual patient. Such genetic variations may identify patients at high risk for the development of sepsis and organ dysfunction during severe infections. Single base variations, known as single nucleotide polymorphisms (SNPs), are the most commonly used variants. There has been great interest in exploring SNP in those genes involved in the inflammatory cascade resulting from the systemic inflammatory response to micro organisms. The rationale for studying gene SNPs in critical illnesses seeks to identify potential markers of susceptibility, severity, and clinical outcome; seeks to identify potential markers for responders and non-responders in clinical trials, and seeks to identify targets for therapeutic intervention. In this review, we focus on the current state of association studies of those genes governing the powerful bacterial infection-induced inflammation and provide guidelines for future studies describing disease associations with genetic variations based on current recommendations. We envision a time in the near future when genotyping will be include in the standard evaluation of critically ill patients and will help to prioritize a therapeutic option.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.