ArticleThe Analyst2004
Ophthalmic glucose sensing: a novel monosaccharide sensing disposable and colorless contact lens.
Article in The Analyst, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Biosensors with Boronic Acid-Based Materials as the Recognition Elements and Signal Labels.Biosensors · 2023Review
- Wearable Smart Contact Lenses for Continual Glucose Monitoring: A Review.Frontiers in medicine · 2022Review
- Ophthalmic Sensors and Drug Delivery.ACS sensors · 2021Review
- Glucose Sensing for Diabetes Monitoring: Recent Developments.Sensors (Basel, Switzerland) · 2017Review
- Smart Sensor Systems for Wearable Electronic Devices.Polymers · 2017Review
- A graphene-based affinity nanosensor for detection of low-charge and low-molecular-weight molecules.Nanoscale · 2016Article
- Thermodynamic Analysis of the Selectivity Enhancement Obtained by Using Smart Hydrogels That Are Zwitterionic When Detecting Glucose With Boronic Acid Moieties.Sensors and actuators. B, Chemical · 2011Article
- Osmotic Swelling Pressure Response of Smart Hydrogels Suitable for Chronically-Implantable Glucose Sensors.Sensors and actuators. B, Chemical · 2010Article
- Analysis of tear glucose concentration with electrospray ionization mass spectrometry.Journal of the American Society for Mass Spectrometry · 2007Article
- Nanogold plasmon resonance-based glucose sensing. 2. Wavelength-ratiometric resonance light scattering.Analytical chemistry · 2005Article
- A glucose-sensing contact lens: from bench top to patient.Current opinion in biotechnology · 2005Review
- Boronic acid fluorescent sensors for monosaccharide signaling based on the 6-methoxyquinolinium heterocyclic nucleus: progress toward noninvasive and continuous glucose monitoring.Bioorganic & medicinal chemistry · 2005Article
- OPHTHALMIC GLUCOSE MONITORING USING DISPOSABLE CONTACT LENSES.Reviews in fluorescence · 2005Article
- Ophthalmic glucose monitoring using disposable contact lenses--a review.Journal of fluorescence · 2004Review
- Nanogold-plasmon-resonance-based glucose sensing.Analytical biochemistry · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have developed a technology for continuous tear glucose monitoring, and therefore potentially blood glucose monitoring, using a daily use, disposable contact lens embedded with sugar-sensing boronic acid containing fluorophores. The novelty of our approach is two fold. Firstly, the notion of sensing extremely low glucose concentrations in tears by our approach, and secondly, the unique compatibility of our new probes with the internal environment of the disposable, off-the-shelf, contact lenses, chosen because the physiological compatibility of disposable plastic contact lenses has already been assessed and optimized with regard to vision correction, size and oxygen/analyte permeability. Our findings show that our approach is indeed suitable for the continuous monitoring of tear glucose levels in the concentration range (50-500 microM), which track blood glucose levels which are approximately 5-10 fold higher. We believe our approach offers unique opportunities for non-invasive continuous glucose monitoring for diabetics, especially since many have eye disorders and require vision correction by either contact lenses or glasses, which is thought to be due to glycation of protein in blood vessels.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.