ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Burst initiation and termination in phasic vasopressin cells of the rat supraoptic nucleus: a combined mathematical, electrical, and calcium fluorescence study.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 84 citations in OpenAlex.
- Phasic spiking in vasopressin neurons: How and Why.Journal of neuroendocrinology · 2021Review
- Phasic Neuronal Firing in the Rodent Nucleus of the Solitary TractFrontiers in physiology · 2021Article
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- Changes in potassium channel modulation may underlie afterhyperpolarization plasticity in oxytocin neurons during late pregnancy.Journal of neurophysiology · 2018Article
- Phosphatidylinositol 4,5-bisphosphate (PIPThe Journal of physiology · 2017Article
- Spike patterning in oxytocin neurons: Capturing physiological behaviour with Hodgkin-Huxley and integrate-and-fire models.PloS one · 2017Article
- Modulation of spike clustering by NMDA receptors and neurotensin in rat supraoptic nucleus neurons.The Journal of physiology · 2014Article
- Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH.Endocrine · 2014Review
- μ-Opioid inhibition of Ca2+ currents and secretion in isolated terminals of the neurohypophysis occurs via ryanodine-sensitive Ca2+ stores.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Information coding in vasopressin neurons--the role of asynchronous bistable burst firing.Bio Systems · 2013Article
- Quantitative prediction of vasopressin secretion using a computational population model of rat magnocellular neurons.Journal of computational neuroscience · 2012Article
- Phasic firing in vasopressin cells: understanding its functional significance through computational models.PLoS computational biology · 2012Article
- New determinants of firing rates and patterns of vasopressinergic magnocellular neurons: predictions using a mathematical model of osmodetection.Journal of computational neuroscience · 2011Article
- Biocytin-labelling and its impact on late 20th century studies of cortical circuitry.Brain research reviews · 2011Article
- Voltage-dependent kappa-opioid modulation of action potential waveform-elicited calcium currents in neurohypophysial terminals.Journal of cellular physiology · 2010Article
- Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis.BMC physiology · 2010Article
- Performance, properties and plasticity of identified oxytocin and vasopressin neurones in vitro.Journal of neuroendocrinology · 2010Review
- Synchronized bursts of miniature inhibitory postsynaptic currents.The Journal of physiology · 2010Article
- Glutamatergic inputs contribute to phasic activity in vasopressin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Vasopressin secreting neurons of the rat hypothalamus discharge lengthy, repeating bursts of action potentials in response to physiological stress. Although many electrical currents and calcium-dependent processes have been isolated and analyzed in these cells, their interactions are less well fathomed. In particular, the mechanism of how each burst is triggered, sustained, and terminated is poorly understood. We present a mathematical model for the bursting mechanism, and we support our model with new simultaneous electrical recording and calcium imaging data. We show that bursts can be initiated by spike-dependent calcium influx, and we propose that the resulting elevation of bulk calcium inhibits a persistent potassium current. This inhibition depolarizes the cell above threshold and so triggers regenerative spiking and further calcium influx. We present imaging data to show that bulk calcium reaches a plateau within the first few seconds of the burst, and our model indicates that this plateau occurs when calcium influx is balanced by efflux and uptake into stores. We conjecture that the burst is terminated by a slow, progressive desensitization to calcium of the potassium leak current. Finally, we propose that the opioid dynorphin, which is known to be secreted from the somatodendritic region and has been shown previously to regulate burst length and phasic activity in these cells, is the autocrine messenger for this desensitization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.