Evidence map›Paper›PMID 15150603›Full record

ArticleBritish journal of cancer2004

Childhood leukaemia incidence and the population mixing hypothesis in US SEER data.

D Wartenberg, D Schneider, S Brown

Abstract readComparative Study
In one paragraph

Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

D WartenbergUMDNJ-Robert Wood Johnson Medical School, The Cancer Institute of New Jersey, New Brunswick, NJ, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA. Dan.Wartenburg@umdnj.edu
D Schneider
S Brown

Funding

Geographic Tools for Surveillance and Study of DiseaseR01CA092693 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI WARTENBERG, DANIEL · 2001 to 2003
$814k
NCI NIH HHS R01 CA092693NCI NIH HHS R01 CA 92693
6 · The paper itself

Abstract

We evaluated the infectious aetiology hypothesis of childhood leukaemia that rapid population influx into rural areas is associated with increased risk. Using data from the US SEER program, we found that in changes in rural county population sizes from 1980 to 1989 were associated with incidence rates for childhood acute lymphocytic leukaemia (ALL). The observed associations were strongest among children 0-4 years of age, born in the same state as diagnosis, in extremely rural counties, and when counties adjacent to nonrural counties were excluded. Similar analyses for brain and central nervous system (CNS) cancer in children, a disease less linked to this infectious hypothesis, provide evidence against methodologic bias. Similar evaluations for other decades were not meaningful due to limited sample sizes and, perhaps, increased population mobility.

Indexed as

Population DynamicsSEER ProgramAdolescentAge FactorsCentral Nervous System NeoplasmsChildChild, PreschoolHumansIncidenceInfantInfant, NewbornPrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsRural PopulationUnited States

Identifiers

PMID15150603
PMCPMC2409734

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.