ArticleJournal of bacteriology2004
The ETT2 gene cluster, encoding a second type III secretion system from Escherichia coli, is present in the majority of strains but has undergone widespread mutational attrition.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Quorum-sensing regulator LsrR modulates avian pathogenicInfection and immunity · 2026Article
- Escherichia coli Type III Secretion System 2 Is Associated With Patient Mortality in Bloodstream Infections.The Journal of infectious diseases · 2025Article
- Genomic island-encoded regulatory proteins in enterohemorrhagicVirulence · 2024Review
- Genetic distribution, characterization, and function ofiScience · 2024Review
- Genomic and Phenotypic Characterization of Shiga Toxin-ProducingMicroorganisms · 2023Article
- Global Genomic Epidemiology ofMicroorganisms · 2022Article
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- Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Transcription Regulator YgeK Affects the Virulence of Avian PathogenicAnimals : an open access journal from MDPI · 2021Article
- Characterisation of Early PositiveAntibiotics (Basel, Switzerland) · 2021Article
- DctR contributes to the virulence of avian pathogenic Escherichia coli through regulation of type III secretion system 2 expression.Veterinary research · 2021Article
- Added Value of Genomic Surveillance of Virulence Factors in Shiga Toxin-ProducingFrontiers in microbiology · 2021Article
- Transcriptional Regulator YqeI, Locating at ETT2 Locus, Affects the Pathogenicity of Avian PathogenicAnimals : an open access journal from MDPI · 2020Article
- Review
- Article
- Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions.Cellular microbiology · 2020Review
- A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage.Scientific reports · 2020Article
- New Insights Into DAEC and EAEC Pathogenesis and Phylogeny.Frontiers in cellular and infection microbiology · 2020Article
- Article
- Article
6 more citing papers are in PubMed but not listed here.
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Abstract
ETT2 is a second cryptic type III secretion system in Escherichia coli which was first discovered through the analysis of genome sequences of enterohemorrhagic E. coli O157:H7. Comparative analyses of Escherichia and Shigella genome sequences revealed that the ETT2 gene cluster is larger than was previously thought, encompassing homologues of genes from the Spi-1, Spi-2, and Spi-3 Salmonella pathogenicity islands. ETT2-associated genes, including regulators and chaperones, were found at the same chromosomal location in the majority of genome-sequenced strains, including the laboratory strain K-12. Using a PCR-based approach, we constructed a complete tiling path through the ETT2 gene cluster for 79 strains, including the well-characterized E. coli reference collection supplemented with additional pathotypes. The ETT2 gene cluster was found to be present in whole or in part in the majority of E. coli strains, whether pathogenic or commensal, with patterns of distribution and deletion mirroring the known phylogenetic structure of the species. In almost all strains, including enterohemorrhagic E. coli O157:H7, ETT2 has been subjected to varying degrees of mutational attrition that render it unable to encode a functioning secretion system. A second type III secretion system-associated locus that likely encodes the ETT2 translocation apparatus was found in some E. coli strains. Intact versions of both ETT2-related clusters are apparently present in enteroaggregative E. coli strain O42.
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