ArticleJournal of bacteriology2004
Bacteriophage Tuc2009 encodes a tail-associated cell wall-degrading activity.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 94 citations in OpenAlex.
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- One fold, many functions-M23 family of peptidoglycan hydrolases.Frontiers in microbiology · 2022Review
- Novel Genus of Phages Infecting Streptococcus thermophilus: Genomic and Morphological Characterization.Applied and environmental microbiology · 2020Article
- Phage-Derived Antibacterials: Harnessing the Simplicity, Plasticity, and Diversity of Phages.Viruses · 2019Review
- Molecular Basis of Bacterial Host Interactions by Gram-Positive Targeting Bacteriophages.Viruses · 2018Review
- A Decade of Streptococcus thermophilus Phage Evolution in an Irish Dairy Plant.Applied and environmental microbiology · 2018Article
- Review of the nature, diversity and structure of bacteriophage receptor binding proteins that target Gram-positive bacteria.Biophysical reviews · 2018Review
- Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process.Applied microbiology and biotechnology · 2017Review
- Global Survey and Genome Exploration of Bacteriophages Infecting the Lactic Acid BacteriumFrontiers in microbiology · 2017Article
- Bacteriophages and Their Immunological Applications against Infectious Threats.Journal of immunology research · 2017Review
- Functional and structural dissection of the tape measure protein of lactococcal phage TP901-1.Scientific reports · 2016Article
- Identification and Analysis of a Novel Group of Bacteriophages Infecting the Lactic Acid Bacterium Streptococcus thermophilus.Applied and environmental microbiology · 2016Article
- The Baseplate of Lactobacillus delbrueckii Bacteriophage Ld17 Harbors a Glycerophosphodiesterase.The Journal of biological chemistry · 2016Article
- Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages.Scientific reports · 2016Article
- Lactococcal 949 group phages recognize a carbohydrate receptor on the host cell surface.Applied and environmental microbiology · 2015Article
- Novel phage group infecting Lactobacillus delbrueckii subsp. lactis, as revealed by genomic and proteomic analysis of bacteriophage Ldl1.Applied and environmental microbiology · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuc2009 is a P335-type member of the tailed-phage supergroup Siphoviridae and was originally identified as a resident prophage of the gram-positive bacterium Lactococcus lactis UC509. A Tuc2009 gene designated tal2009 which is located within the morphogenic module was shown to specify a lytic activity within the 3' portion of its coding region. Comparative sequence analysis indicated that the cell wall-degrading part of Tal2009 is a member of the M37 protein family and that Tal2009 lacks a cell-binding domain, a finding supported by binding studies. Tal2009 appears to undergo self-mediated posttranslational processing in both L. lactis and Escherichia coli. Antibodies directed against a purified C-terminal portion of Tal2009 were used for immunoelectron microscopy, which showed that Tal2009 is located at the tail tip of Tuc2009. Antibody neutralization studies demonstrated that Tal2009-directed antibodies inhibited the ability of phage to mediate host lysis by more than 100-fold. These data indicate that tal2009 encodes a tail-associated lysin involved in localized cell wall degradation, thus allowing the Tuc2009 DNA injection machinery access to the membrane of its bacterial host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.