ArticleJournal of bacteriology2004
Stress response gene regulation in Chlamydia is dependent on HrcA-CIRCE interactions.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- A Refined Developmental Transcriptomic Landscape Reveals Four Coordinated Programs inbioRxiv : the preprint server for biology · 2026Article
- Comparative transcriptomics reveals genes commonly induced by distinct stressors inInfection and immunity · 2026Article
- Comparative Transcriptomics Reveals Genes Commonly Induced by Distinct Stressors inbioRxiv : the preprint server for biology · 2025Article
- A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress.bioRxiv : the preprint server for biology · 2025Article
- Chlamydia trachomatis RsbU Phosphatase Activity Is Inhibited by the Enolase Product, Phosphoenolpyruvate.Journal of bacteriology · 2022Article
- Article
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- The Repressor Function of theJournal of bacteriology · 2020Article
- Regulatory (pan-)genome of an obligate intracellular pathogen in the PVC superphylum.The ISME journal · 2016Article
- Following the Footsteps of Chlamydial Gene Regulation.Molecular biology and evolution · 2015Article
- Transcriptional regulation of the Chlamydia heat shock stress response in an intracellular infection.Molecular microbiology · 2015Article
- The early gene product EUO is a transcriptional repressor that selectively regulates promoters of Chlamydia late genes.Molecular microbiology · 2012Article
- Differential effects of DNA supercoiling on Chlamydia early promoters correlate with expression patterns in midcycle.Journal of bacteriology · 2012Article
- A Chlamydia-specific C-terminal region of the stress response regulator HrcA modulates its repressor activity.Journal of bacteriology · 2011Article
- Isolation and characterization of Ehrlichia chaffeensis RNA polymerase and its use in evaluating p28 outer membrane protein gene promoters.BMC microbiology · 2011Article
- Promoter analysis of macrophage- and tick cell-specific differentially expressed Ehrlichia chaffeensis p28-Omp genes.BMC microbiology · 2009Article
- DNA supercoiling-dependent gene regulation in Chlamydia.Journal of bacteriology · 2008Article
- Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival.BMC microbiology · 2006Article
- Molecular mechanism of tryptophan-dependent transcriptional regulation in Chlamydia trachomatis.Journal of bacteriology · 2006Article
- Chlamydial GroEL autoregulates its own expression through direct interactions with the HrcA repressor protein.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
HrcA is a transcriptional repressor that regulates stress response genes in many bacteria by binding to the CIRCE operator. We have previously shown that HrcA regulates the promoter for the dnaK heat shock operon in Chlamydia. Here we demonstrate that HrcA represses a second heat shock promoter that controls the expression of groES and groEL, two other major chlamydial heat shock genes. The CIRCE element of C. trachomatis groEL is the most divergent of known bacterial CIRCE elements, and HrcA had a decreased ability to bind to this nonconsensus operator and repress transcription. We demonstrate that the CIRCE element is necessary and sufficient for transcriptional regulation by chlamydial HrcA and that the inverted repeats of CIRCE are the binding sites for HrcA. Addition of a CIRCE element upstream of a non-heat-shock promoter allowed this promoter to be repressed by HrcA, showing in principle that a chlamydial promoter can be genetically modified to be inducible. These results demonstrate that HrcA is the regulator of the major chlamydial heat shock operons, and we infer that the mechanism of the heat shock response in Chlamydia is derepression. However, derepression is likely to involve more than a direct effect of increased temperature as we found that HrcA binding to CIRCE and HrcA-mediated repression were not altered at temperatures that induce the heat shock response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.