ArticleJournal of molecular medicine (Berlin, Germany)2004
A new role for expressed pseudogenes as ncRNA: regulation of mRNA stability of its homologous coding gene.
Article in Journal of molecular medicine (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- MRKNs: Gene, Functions, and Role in Disease and Infection.Frontiers in oncology · 2022Review
- Virtual Gene Concept and a Corresponding Pragmatic Research Program in Genetical Data Science.Entropy (Basel, Switzerland) · 2021Review
- Concerted and birth-and-death evolution of 26S ribosomal DNA in Camellia L.Annals of botany · 2021Article
- Complex Analysis of Retroposed Genes' Contribution to Human Genome, Proteome and Transcriptome.Genes · 2020Article
- dreamBase: DNA modification, RNA regulation and protein binding of expressed pseudogenes in human health and disease.Nucleic acids research · 2018Article
- Differentially-Expressed Pseudogenes in HIV-1 Infection.Viruses · 2015Article
- Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells.PloS one · 2014Article
- Characterization of human pseudogene-derived non-coding RNAs for functional potential.PloS one · 2014Article
- "Orphan" retrogenes in the human genome.Molecular biology and evolution · 2013Article
- Pseudogenes: pseudo-functional or key regulators in health and disease?RNA (New York, N.Y.) · 2011Review
- Identification of three prominin homologs and characterization of their messenger RNA expression in Xenopus laevis tissues.Molecular vision · 2011Article
- Evolutionary and expression signatures of pseudogenes in Arabidopsis and rice.Plant physiology · 2009Article
- HLA associations with nasopharyngeal carcinoma.Current molecular medicine · 2009Review
- Small RNAs originated from pseudogenes: cis- or trans-acting?PLoS computational biology · 2009Article
- Oncogenic activation of MAP kinase by BRAF pseudogene in thyroid tumors.Neoplasia (New York, N.Y.) · 2009Article
- Pseudogenes in the ENCODE regions: consensus annotation, analysis of transcription, and evolution.Genome research · 2007Article
- The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Genomic signatures of positive selection in humans and the limits of outlier approaches.Genome research · 2006Article
- Genome-wide survey for biologically functional pseudogenes.PLoS computational biology · 2006Article
- Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals.Genetics · 2006Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have earlier generated a mutant mouse in a course of making a transgenic line that exhibited interesting heterozygote phenotypes, which exhibited failure to thrive, severe bone deformities, and polycystic kidneys. This mutant mouse provided a clue to uncover a unique role of expressed pseudogenes. In this mutant the transgene was integrated into the vicinity of the expressing pseudogene of Makorin1 called Makorin1-p1. This insertion reduced transcription of the Makorin1-p1, resulting in destabilization of the Makorin1 mRNA in trans via a cis-acting RNA decay element within the 5' region of Makorin1 that is homologous between Makorin1 and Makorin1-p1. These findings demonstrate a novel and specific regulatory role of an expressed pseudogene as well as functional significance for noncoding RNAs. Next, we developed an original algorithm to determine how many pseudogenes are expressed. Based on our examination 2-3% of human processed pseudogenes are expressed using the most strict criteria. Interestingly, the mouse has a much smaller proportion of expressed pseudogenes (0.5-1%). Pseudogenes are functionally less constrained, and have accumulated more mutations than translated genes. If they have some functions in gene regulation, this property would allow more rapid functional diversification than protein-coding genes. In addition, some genetic phenomena that exhibit incomplete penetrance might be attributed to "mutation" or "variation" of pseudogenes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.