ArticleIntensive care medicine2004
Practices in non-neutropenic ICU patients with Candida-positive airway specimens.
Article in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Brazilian guidelines for the management of candidiasis - a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesGuideline
- Article
- Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study.Intensive care medicine · 2019Article
- Respiratory Tract Colonization byClinical pulmonary medicine · 2018Article
- Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study.BMC infectious diseases · 2017Observational
- Assessing Complex Emergency Management with Clinical Case-Vignettes: A Validation Study.PloS one · 2015Article
- Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia.Thorax · 2010Article
- Year in review in Intensive Care Medicine 2009: I. Pneumonia and infections, sepsis, outcome, acute renal failure and acid base, nutrition and glycaemic control.Intensive care medicine · 2010Review
- Clinical review: What is the role for autopsy in the ICU?Critical care (London, England) · 2010Review
- [Update: invasive fungal infections: Diagnosis and treatment in surgical intensive care medicine].Der Anaesthesist · 2010Review
- Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy study.Intensive care medicine · 2009Article
- Candida pneumonia in the ICU: myth or reality?Intensive care medicine · 2009Article
- Epidemiology, incidence and risk factors for invasive candidiasis in high-risk patients.Drugs · 2009Review
- Invasive candidiasis in pediatric intensive care patients: epidemiology, risk factors, management, and outcome.Intensive care medicine · 2007Review
- Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study.Intensive care medicine · 2007Article
- Candida sp. isolated from bronchoalveolar lavage: clinical significance in critically ill trauma patients.Intensive care medicine · 2006Article
- Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis.Intensive care medicine · 2005Review
- Rapid detection of Candida species in bronchoalveolar lavage fluid from patients with pulmonary symptoms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
- Respiratory tract colonization withInternational journal of critical illness and injury scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine practices of French intensivists regarding the management of mechanically ventilated patients with Candida-positive airway specimens but no major risk factors for immunodepression. Design : Closed-item questionnaire with a clinical vignette.
setting564 French intensive care units (ICUs).
participants198 intensivists who have a special interest in infectious diseases and who answered the questionnaire (response rate, 35.1%).
interventionNone. MEASUREMENTS AND
resultsThe respondents recommended bronchoalveolar lavage (62.6% of respondents), protected distal sampling and protected specimen brush (59.1%), transbronchial biopsy (38.9%), and tracheal aspiration (12.1%) for the diagnosis of candidal pneumonia. A positive airway specimen was felt by most respondents (83.3%) to indicate colonisation; 66.7% of respondents recommended tests for systemic candidiasis in this situation, and 56.5% serial sampling to compute the colonisation index. Azole derivatives were the preferred antifungal medications. The clinical vignette described a patient with chronic obstructive lung disease who required mechanical ventilation for an acute exacerbation and who had a tracheal aspirate positive for Candida. Responses varied widely, with 37.8% of respondents diagnosing clinically insignificant colonisation but 24.2% recommending antifungal treatment and 61.6% serial testing to assess the Candida colonisation index. Intensivists with greater experience with severely immunocompromised patients were more aggressive in their diagnostic management.
conclusionsWide variations occur among practices of French intensivists regarding Candida-positive airway specimens in patients without major risk factors for immunodepression. Additional studies are needed to improve our understanding of the links between Candida colonisation and infection and to determine the indications for pre-emptive antifungal treatment in non-neutropenic critically ill patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.