ArticleProceedings of the National Academy of Sciences of the United States of America2004
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- PDE5 Inhibitors as Modulators of Alzheimer's-Associated Inflammation and Oxidative Stress: A Meta-Analytical Assessment of Preclinical Studies.Molecular neurobiology · 2025Pooled it
- IFNγ-Induced Bcl3, PD-L1 and IL-8 Signaling in Ovarian Cancer: Mechanisms and Clinical Significance.Cancers · 2024Review
- The Role of the Nuclear Factor-Kappa B (NF-κB) Pathway in SARS-CoV-2 Infection.Pathogens (Basel, Switzerland) · 2024Review
- Estrogen receptor α-mediated signaling inhibits type I interferon response to promote breast carcinogenesis.Journal of molecular cell biology · 2024Article
- NF-κB signalling as a pharmacological target in COVID-19: potential roles for IKKβ inhibitors.Naunyn-Schmiedeberg's archives of pharmacology · 2021Review
- IL-12-mediated transcriptional regulation of matrix metalloproteinases.Bioscience reports · 2018Article
- SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense againstProceedings of the National Academy of Sciences of the United States of America · 2017Article
- A role for human brain pericytes in neuroinflammation.Journal of neuroinflammation · 2014Article
- The Role of F-Box Proteins during Viral Infection.International journal of molecular sciences · 2013Article
- NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.Molecular and cellular biology · 2011Article
- Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γ.PLoS pathogens · 2011Article
- Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease.Parkinson's disease · 2011Article
- Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy.Scientific reports · 2011Article
- The IKK Kinases: Operators of Antiviral Signaling.Viruses · 2010Article
- Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2009Article
- Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism.PLoS pathogens · 2009Article
- Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2008Article
- Molecular mechanisms of uterine leiomyosarcomas: involvement of defect in LMP2 expression.Gene regulation and systems biology · 2008Article
- Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
IkappaB kinase (IKK), discovered as the major activator of NF-kappaB, plays additional roles in signaling. By using mouse embryo fibroblasts (MEFs) lacking both the alpha and beta subunits of IKK, we find that these proteins are required for induction of a major subset of IFNgamma-stimulated genes and that this requirement is independent of NF-kappaB activation. Furthermore, there is no defect in IFNgamma-stimulated signal transducer and activator of transcription 1 (Stat1) activation or function in the IKKalpha/beta-null MEFs. Therefore, although activated Stat1 dimers are necessary for the activation of these genes in response to IFNgamma, they are not sufficient. These results reveal an important additional pathway for IFNgamma-stimulated gene expression in which an NF-kappaB-independent function of IKK is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.