ArticleThe Journal of cell biology2004
Carbohydrate-carbohydrate interaction provides adhesion force and specificity for cellular recognition.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Advanced nanotherapies for precision treatment of inflammatory lung diseases.Bioactive materials · 2025Review
- Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads.Communications chemistry · 2024Article
- Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections.Bioactive materials · 2023Article
- Biocorona on Iron Oxide Nanoparticles in a Complex Biotechnological Environment: Analysis of Proteins, Lipids, and Carbohydrates.Small science · 2023Article
- Measuring pico-Newton Forces with Lipid Anchors as Force Sensors in Molecular Dynamics Simulations.The journal of physical chemistry. B · 2023Article
- Self-organization of apical membrane protein sorting in epithelial cells.The FEBS journal · 2022Article
- Nanocarriers surface engineered with cell membranes for cancer targeted chemotherapy.Journal of nanobiotechnology · 2022Review
- Review
- Enhanced Shear Force Responsiveness of Epithelial NaInternational journal of molecular sciences · 2021Article
- Interplay ofFrontiers in molecular biosciences · 2021Article
- The influence of ABO blood groups on COVID-19 susceptibility and severity: A molecular hypothesis based on carbohydrate-carbohydrate interactions.Medical hypotheses · 2020Article
- Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish.The Journal of cell biology · 2020Article
- Re-evaluating the importance of carbohydrates as regenerative biomaterials.Regenerative biomaterials · 2019Review
- Selective enrichment of sialylated glycopeptides with a d-allose@SiORSC advances · 2018Article
- Predicting the Structures of Glycans, Glycoproteins, and Their Complexes.Chemical reviews · 2018Review
- Glycointeractions in bacterial pathogenesis.Nature reviews. Microbiology · 2018Review
- Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery.Acta pharmaceutica Sinica. B · 2018Review
- Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate-Carbohydrate Interactions.ACS macro letters · 2018Article
- Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.Scientific reports · 2018Article
- Direct comparison of derivatization strategies for LC-MS/MS analysis of N-glycans.The Analyst · 2017Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adhesion force and specificity in the first experimental evidence for cell-cell recognition in the animal kingdom were assigned to marine sponge cell surface proteoglycans. However, the question whether the specificity resided in a protein or carbohydrate moiety could not yet be resolved. Here, the strength and species specificity of cell-cell recognition could be assigned to a direct carbohydrate-carbohydrate interaction. Atomic force microscopy measurements revealed equally strong adhesion forces between glycan molecules (190-310 piconewtons) as between proteins in antibody-antigen interactions (244 piconewtons). Quantitative measurements of adhesion forces between glycans from identical species versus glycans from different species confirmed the species specificity of the interaction. Glycan-coated beads aggregated according to their species of origin, i.e., the same way as live sponge cells did. Live cells also demonstrated species selective binding to glycans coated on surfaces. These findings confirm for the first time the existence of relatively strong and species-specific recognition between surface glycans, a process that may have significant implications in cellular recognition.
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Registered trials
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