ArticleBritish journal of pharmacology2004
Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Contractile effects and receptor analysis of adenosine-receptors in human detrusor muscle from stable and neuropathic bladders.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Medicinal chemistry of adenosine, P2Y and P2X receptors.Neuropharmacology · 2016Review
- The purinergic neurotransmitter revisited: a single substance or multiple players?Pharmacology & therapeutics · 2014Review
- Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.British journal of pharmacology · 2014Article
- Purinergic inhibitory regulation of murine detrusor muscles mediated by PDGFRα+ interstitial cells.The Journal of physiology · 2014Article
- Purinergic signalling in the urinary tract in health and disease.Purinergic signalling · 2014Review
- Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- The impact of commercially available purinergic ligands on purinergic signalling research.Purinergic signalling · 2012Article
- Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Purinergic mechanosensory transduction and visceral pain.Molecular pain · 2009Review
- Expression and function of rat urothelial P2Y receptors.American journal of physiology. Renal physiology · 2008Article
- Purinoceptors as therapeutic targets for lower urinary tract dysfunction.British journal of pharmacology · 2006Review
- Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red.British journal of pharmacology · 2005Article
- Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats.British journal of pharmacology · 2004Article
- Extracellular adenosine 5'-triphosphate concentrations changes in rat spinal cord associated with the activation of urinary bladder afferents. A microdialysis study.Einstein (Sao Paulo, Brazil)Article
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4 authors.
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Abstract
1 The effects of purinoceptor ligands for P2X1 and/or P2X3 receptors (alpha,beta-meATP, IP(5)I, TNP-ATP, MRS 2179, PPADS, Phenol red and RO116-6446/008; i.v., n=4-5) and for P2Y1 receptors (PPADS, MRS 2179 and MRS 2269; i.v., n=3-5) were investigated on the distension-evoked 'micturition reflex' in the urethane-anaesthetized female rat. 2 Alpha,beta-meATP (180 nmol kg(-1) min(-1)), IP5I (10, 30 and 100 nmol kg(-1)), TNP-ATP (1 micromol kg(-1)), MRS 2179 (1 micromol kg(-1)) and PPADS (17 micromol kg(-1)) each caused maintained bladder contractions to occur during the infusion of saline into the bladder. PPADS (17 micromol kg(-1) min(-1)) had a similar effect when infused intravesicularly. Regular bladder contractions were not observed until the infusion of saline was halted. For IP5I, TNP-ATP, MRS 2179 and PPADS, the magnitude of postinfusion isovolumetric contractions was significantly reduced and, for IP5I, this action was also associated with a significant reduction in urethral relaxation. Additionally, TNP-ATP caused a significant increase in the pressure and volume thresholds required to initiate a reflex. 3 Phenol red (a P2X1/P2X3 antagonist; 0.1 and 1 micromol kg(-1)) caused a significant increase in the pressure and volume thresholds required to initiate a reflex and, at the higher dose, also caused a reduction in postinfusion isovolumetric contractions. 4 RO116-6446/008 (a P2X1-selective antagonist; 1 and 10 micromol kg(-1)) only caused a reduction in postinfusion isovolumetric contractions. 5 It is concluded that P2X1 and P2X3 receptors play a fundamental role in the micturition reflex in urethane-anesthetized female rats. P2X3 receptor blockade raised the pressure and volume thresholds for the reflex, whereas P2X1 receptor blockade diminished motor activity associated with voiding. P2Y1 receptors may be involved in inhibition of rat detrusor tone.
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