ArticleBritish journal of pharmacology2004
Experimental hypothyroidism modifies specific binding of A1 and A2A analogues to adenosine receptors in the rat kidney.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Purinergic signalling in the kidney in health and disease.Purinergic signalling · 2014Review
- Pleiotropic effects of thyroid hormones: learning from hypothyroidism.Journal of thyroid research · 2011Article
- Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymes activities.BMC nephrology · 2005Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
1 Binding kinetic studies with the adenosine analogues [3H]CPA (0.250-50 nm) and [3H]CGS21680 (0.1-100 nm) were performed in renal tissue from control (NL) and thyroidectomised (HTX) rats. We propose that the low renal adenosine content reported in hypothyroid rats may induce changes in the density and/or affinity of adenosine receptor, distributed in the cortex (C), outer medulla (OM), and inner medulla (IM) of the kidney. 2 [3H]CPA and [3H]CGS21680 binding saturation isotherms were fitted by nonlinear regression analysis and evaluated by Furchgott's method. These results revealed high (KH) and low (KL) affinity (KD) sites for both compounds. As expected, a heterogeneous pattern was observed for Bmax and KD values. 3 Bound [3H]CPA and [3H]CGS21680 were displaced by increasing concentrations of nonlabelled DPCPX and NECA, respectively, indicating the presence of A1 and A2A adenosine receptors distributed in the renal segments studied. 4 The relative intrinsic efficacy (epsilon) for [3H]CPA and [3H]CGS21680 showed extreme values (far from 1.0), 0.5 in IM NL and 2.70 in IM HTX for [3H]CGS21680. 5 Our results indicate that A2A adenosine receptor is predominant in IM from HTX, but A1 receptors are expressed preferentially in C in NL. 6 We conclude that the changes observed in number, affinity, and epsilon for the A2A receptor in IM from HTX might be responsible from alterations in medullary function, that is, incapacity for urine concentration as observed in the hypothyroid kidney.
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