ArticleClinical and experimental immunology2004
Langerhans cells from human oral epithelium are more effective at stimulating allogeneic T cells in vitro than Langerhans cells from skin.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions.Journal of personalized medicine · 2024Review
- Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry.The Japanese dental science review · 2021Review
- Innate Phagocyte Polarization in the Oral Cavity.Frontiers in immunology · 2021Review
- Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy.PloS one · 2018Article
- Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin.PloS one · 2017Article
- Mucosal vaccine delivery: Current state and a pediatric perspective.Journal of controlled release : official journal of the Controlled Release Society · 2016Review
- Vaccine delivery to the oral cavity using coated microneedles induces systemic and mucosal immunity.Pharmaceutical research · 2014Article
- Dendritic cells of the oral mucosa.Mucosal immunology · 2014Review
- Langerhans cells and their role in oral mucosal diseases.North American journal of medical sciences · 2013Review
- Mechanisms of viral infections associated with HIV: workshop 2B.Advances in dental research · 2011Article
- Porphyromonas gingivalis induces CCR5-dependent transfer of infectious HIV-1 from oral keratinocytes to permissive cells.Retrovirology · 2008Article
- Dendritic cells at the oral mucosal interface.Journal of dental research · 2006Review
- The Current Understanding on Langerhans' Cells and Its Role in Oral Lesions.Contemporary clinical dentistryReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report is focused on the functional capacity of Langerhans cells (LC) in the epithelium of skin and oral mucosa, which both meet different antigenic challenges. The capacity of LC from human oral and skin epithelium to provide co-stimulatory signals to T cells in vitro was compared. LC in a crude suspension of oral epithelial cells had a significantly enhanced T cell co-stimulatory capacity compared to skin epithelial cells. This applied both to cultures with concanavalin A (con-A)-stimulated syngeneic T cells and to a mixed epithelial cell lymphocyte reaction involving allogeneic T cells. The co-stimulatory capacity of oral and skin epithelial cells was reduced by >70% if monoclonal antibodies against HLA-DR, -DP and -DQ were added to the cultures with allogeneic T cells, indicating the involvement of HLA class II expressing LC. Immunohistochemistry revealed that 6% of the epithelial cells were CD1a + LC in sections from both oral and skin epithelium. Interleukin (IL)-8 production was higher in cultures of oral epithelial cells and con-A stimulated T cells than in corresponding cultures with skin epithelial cells as accessory cells. The results suggest that LC in human oral epithelium are more efficient at stimulating T cells than those of skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.