ArticleEuropean journal of clinical pharmacology2004
Off-label prescribing to children in primary care: retrospective observational study.
Article in European journal of clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Younger Children with Respiratory Tract Infections Are More Exposed to Off-Label Treatments: An Exploratory Retrospective Study in a Pediatric Emergency Setting.Children (Basel, Switzerland) · 2024Article
- Off-label Medications Use in the Eastern Province of Saudi Arabia: The Views of General Practitioners, Pediatricians, and Other Specialists.Hospital pharmacy · 2020Article
- Two decades of off-label prescribing in children: a literature review.World journal of pediatrics : WJP · 2018Review
- Trends in Outpatient Prescription Medicine Use in New Zealand Children 2010-2015: A National Population-Based Study.Paediatric drugs · 2018Article
- Off-label drug use in hospitalized children: a prospective observational study at Gondar University Referral Hospital, Northwestern Ethiopia.Pharmacology research & perspectives · 2017Article
- Article
- Off-label prescribing of psychotropic drugs in a Danish child and adolescent psychiatric outpatient clinic.European child & adolescent psychiatry · 2016Article
- 'The more you link, the more you risk …' - a focus group study exploring views about data linkage for pharmacovigilance.British journal of clinical pharmacology · 2014Article
- Off-label prescribing for allergic diseases in children.The World Allergy Organization journal · 2014Article
- Off-label medicine use in children and adolescents: results of a population-based study in Germany.BMC public health · 2013Article
- Off-label prescriptions for adult neurological patients: a pilot survey in China.International journal of clinical pharmacy · 2012Article
- Paracetamol prescribing in primary care: too little and too much?British journal of clinical pharmacology · 2011Article
- Paediatric drug use with focus on off-label prescriptions in Swedish outpatient care--a nationwide study.Acta paediatrica (Oslo, Norway : 1992) · 2011Article
- Prescribing of medicines in the Danish paediatric population outwith the licensed age group: characteristics of adverse drug reactions.British journal of clinical pharmacology · 2011Article
- Healthcare professional experiences and attitudes on unlicensed/off-label paediatric prescribing and paediatric clinical trials.European journal of clinical pharmacology · 2011Article
- Dose variations associated with formulations of NSAID prescriptions for children: a descriptive analysis of electronic health records in the UK.Drug safety · 2011Article
- Trends in utilization and off-label use of polyethylene glycol 4000 laxatives and the prevalence of constipation in children in France.Clinical and experimental gastroenterology · 2011Article
- Prescribing patterns of asthma controller therapy for children in UK primary care: a cross-sectional observational study.BMC pulmonary medicine · 2010Article
- Drug utilization and off-label drug use among Spanish emergency room paediatric patients.European journal of clinical pharmacology · 2010Article
- How well are general practice trainees prepared for paediatric prescribing?British journal of clinical pharmacology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the extent and pattern of off-label prescribing to children in primary care throughout Scotland.
designAssessment of prescribing to 167,865 children aged 0-16 years during the period November 1999 to October 2000 using data from 161 general practices using the national Scottish primary care computer system General Practice Administration System for Scotland.
settingOne hundred and sixty one general practices in Scotland.
resultsDuring the study period, at least one off-label prescription was issued to 17,715 (26.1%) children aged 0-16 years. Off-label prescribing due to lower than the recommended dose was the most common form of off-label prescribing (40-50%), with antibiotics and antihistamines making up the majority. Off-label prescribing due to higher than the recommended dose was also common (35% of all off-label prescribing), with antiasthmatics, topical corticosteroids and laxatives making up the majority. Off-label prescribing with respect to age was less common (6-16%) affecting mainly young children (less than 2 years old) and adolescents. Off-label prescribing with respect to formulation was the least common cause accounting for 5-10% of off-label prescribing.
conclusionsThis is the largest and most detailed study to date of paediatric off-label prescribing in primary care within the UK. Such off-label prescribing likely occurs as the result of several factors including a failure to update licensing information with currently accepted practice and confusion or unawareness of the licensing recommendations, further compounded by a lack of clinical trials data and suitable formulations for medicines commonly prescribed to young children and adolescents.
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