ReviewThe Journal of clinical investigation2004
Dissecting the functional role of different isoforms of the L-type Ca2+ channel.
Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- The adipocyte-enriched secretory protein tetranectin exacerbates type 2 diabetes by inhibiting insulin secretion from β cells.Science advances · 2022Article
- Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential.Cells · 2020Article
- Calcium channel autoantibodies predicted sudden cardiac death and all-cause mortality in patients with ischemic and nonischemic chronic heart failure.Disease markers · 2014Article
- Agonist-like autoantibodies against calcium channel in patients with dilated cardiomyopathy.Heart and vessels · 2012Article
- Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation.The Journal of biological chemistry · 2010Article
- Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.The Journal of cell biology · 2009Article
- Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels.British journal of pharmacology · 2007Article
- Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Müller cells.Japanese journal of ophthalmologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There currently exist a great number of different mouse lines in which the activity of a particular gene of interest has been inactivated or enhanced. However, it is also possible to insert specific mutations in a gene so that the pharmacological sensitivity of the gene product is altered. An example of such an approach shows how the abolition of the sensitivity of an L-type Ca(2+) channel isoform to dihydropyridines allows the investigation of the physiological role of these channels in different tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.