ArticleRNA (New York, N.Y.)2004
Complete cycles of bloodstream trypanosome RNA editing in vitro.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Protein Complex Map of Trypanosoma brucei.PLoS neglected tropical diseases · 2016Article
- Mitochondrial and nucleolar localization of cysteine desulfurase Nfs and the scaffold protein Isu in Trypanosoma brucei.Eukaryotic cell · 2014Article
- Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.RNA (New York, N.Y.) · 2011Article
- RNA editing complex interactions with a site for full-round U deletion in Trypanosoma brucei.RNA (New York, N.Y.) · 2006Article
- RBP16 stimulates trypanosome RNA editing in vitro at an early step in the editing reaction.RNA (New York, N.Y.) · 2006Article
- Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates.Current genetics · 2005Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA editing in kinetoplastid protists is required for the maturation of mitochondrial pre-mRNAs and occurs by protein-catalyzed cycles of uridylate insertion and deletion. During the complex life cycle of Trypanosoma brucei this process is differentially regulated in the mammalian bloodstream and insect procyclic stages. Complementary guide RNAs (gRNAs) direct editing, but the abundance of these transcripts is not developmentally controlled. The establishment of in vitro systems that recreate efficient RNA editing in bloodstream T. brucei would be valuable for mechanistic studies of regulation. Here we describe a robust in vitro system that reconstitutes full cycles of both U insertion and U deletion in bloodstream trypanosomes, and the first direct comparisons of the in vitro systems for strains of mammalian and insect stages.
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