ArticleRNA (New York, N.Y.)2004
Sequence motifs that distinguish ATP(CTP):tRNA nucleotidyl transferases from eubacterial poly(A) polymerases.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Distribution of poly(A) polymerase I in bacteria: an expanded role for horizontal gene transfer.Microbiology (Reading, England) · 2026Article
- The First Poly(A) Polymerase fromInternational journal of molecular sciences · 2026Article
- Insights into the Performance of CusF as a Solubility Tag for Recombinant Protein Expression.International journal of molecular sciences · 2026Article
- Depletion of tRNA CCA-adding enzyme in Mycobacterium tuberculosis leads to polyadenylation of transcripts and precursor tRNAs.Scientific reports · 2023Article
- Acquisition ofMicrobial genomics · 2021Article
- Adaptation of theInternational journal of molecular sciences · 2020Article
- Phylogeny and Evolution of RNA 3'-Nucleotidyltransferases in Bacteria.Journal of molecular evolution · 2019Article
- New Insights into the Relationship between tRNA Processing and Polyadenylation in Escherichia coli.Trends in genetics : TIG · 2019Review
- RNase J is required for processing of a small number of RNAs in Rhodobacter sphaeroides.RNA biology · 2014Article
- Article
- An inhibitory C-terminal region dictates the specificity of A-adding enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Unusual evolution of a catalytic core element in CCA-adding enzymes.Nucleic acids research · 2010Article
- tRNA nucleotidyltransferases: ancient catalysts with an unusual mechanism of polymerization.Cellular and molecular life sciences : CMLS · 2010Review
- Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme.The EMBO journal · 2009Article
- A comparative analysis of two conserved motifs in bacterial poly(A) polymerase and CCA-adding enzyme.Nucleic acids research · 2008Article
- Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme.The EMBO journal · 2008Article
- Evolution of tRNA nucleotidyltransferases: a small deletion generated CC-adding enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Determinants of substrate specificity in RNA-dependent nucleotidyl transferases.Biochimica et biophysica acta · 2008Review
- RNA-specific ribonucleotidyl transferases.RNA (New York, N.Y.) · 2007Review
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
ATP(CTP):tRNA nucleotidyl transferases, tRNA maturing enzymes found in all organisms, and eubacterial poly(A) polymerases, enzymes involved in mRNA degradation, are so similar that until now their biochemical functions could not be distinguished by their amino acid sequence. BLAST searches and analysis with the program "Sequence Space" for the prediction of functional residues revealed sequence motifs which define these two protein families. One of the poly(A) polymerase defining motifs specifies a structure that we propose to function in binding the 3' terminus of the RNA substrate. Similar motifs are found in other homopolyribonucleotidyl transferases. Phylogenetic classification of nucleotidyl tranferases from sequenced genomes reveals that eubacterial poly(A) polymerases have evolved relatively recently and are found only in a small group of bacteria and surprisingly also in plants, where they may function in organelles.
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