ArticleThe Journal of physiology2004
Phasic spike patterning in rat supraoptic neurones in vivo and in vitro.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Modelling vasopressin synthesis and storage dynamics during prolonged osmotic challenge and recovery based on activity dependent upregulation of mRNA transcription.PLoS computational biology · 2026Article
- Heart failure-induced reprogramming of salt-evoked neurovascular coupling in the rat hypothalamus.The Journal of physiology · 2026Article
- Electrophysiological recording of hypothalamic brain regions in vivo using the transpharyngeal surgical approach in the rat.Journal of neuroendocrinology · 2026Review
- Reduced osmoresponsiveness in magnocellular neuroendocrine neurones during chronic salt-loading.The Journal of physiology · 2025Article
- In-vivo properties and functional subtypes of gonadotropin-releasing hormone neurons.iScience · 2025Article
- Local kisspeptin excitation of rat oxytocin neurones in late pregnancy.The Journal of physiology · 2022Article
- The interplay between glutamatergic circuits and oxytocin neurons in the hypothalamus and its relevance to neurodevelopmental disorders.Journal of neuroendocrinology · 2021Review
- Phasic spiking in vasopressin neurons: How and Why.Journal of neuroendocrinology · 2021Review
- Oxytocin, Neural Plasticity, and Social Behavior.Annual review of neuroscience · 2021Review
- Plasticity in Intrinsic Excitability of Hypothalamic Magnocellular Neurosecretory Neurons in Late-Pregnant and Lactating Rats.International journal of molecular sciences · 2021Article
- Effects of datumetine on hippocampal NMDAR activity.Toxicology reports · 2021Article
- Phasic Neuronal Firing in the Rodent Nucleus of the Solitary TractFrontiers in physiology · 2021Article
- Emergent decision-making behaviour and rhythm generation in a computational model of the ventromedial nucleus of the hypothalamus.PLoS computational biology · 2019Article
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- A Predictive, Quantitative Model of Spiking Activity and Stimulus-Secretion Coupling in Oxytocin Neurons.Endocrinology · 2018Article
- Effect of dietary salt intake on epithelial NaThe Journal of physiology · 2017Article
- Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy.The Journal of physiology · 2017Article
- Spike patterning in oxytocin neurons: Capturing physiological behaviour with Hodgkin-Huxley and integrate-and-fire models.PloS one · 2017Article
- The rat suprachiasmatic nucleus: the master clock ticks at 30 Hz.The Journal of physiology · 2016Article
- Oxytocin Neurones: Intrinsic Mechanisms Governing the Regularity of Spiking Activity.Journal of neuroendocrinology · 2016Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In vivo, most vasopressin cells of the hypothalamic supraoptic nucleus fire action potentials in a 'phasic' pattern when the systemic osmotic pressure is elevated, while most oxytocin cells fire continuously. The phasic firing pattern is believed to arise as a consequence of intrinsic activity-dependent changes in membrane potential, and these have been extensively studied in vitro. Here we analysed the discharge patterning of supraoptic nucleus neurones in vivo, to infer the characteristics of the post-spike sequence of hyperpolarization and depolarization from the observed spike patterning. We then compared patterning in phasic cells in vivo and in vitro, and we found systematic differences in the interspike interval distributions, and in other statistical parameters that characterized activity patterns within bursts. Analysis of hazard functions (probability of spike initiation as a function of time since the preceding spike) revealed that phasic firing in vitro appears consistent with a regenerative process arising from a relatively slow, late depolarizing afterpotential that approaches or exceeds spike threshold. By contrast, in vivo activity appears to be dominated by stochastic rather than deterministic mechanisms, and appears consistent with a relatively early and fast depolarizing afterpotential that modulates the probability that random synaptic input exceeds spike threshold. Despite superficial similarities in the phasic firing patterns observed in vivo and in vitro, there are thus fundamental differences in the underlying mechanisms.
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