ArticleThe Journal of physiology2004
Desensitization of the mGluR6 transduction current in tiger salamander On bipolar cells.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- High-Pressure Freezing EM Tomography of Entire Ribbon Synapses in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Divergent mechanisms of neural adaptation and instability in the mammalian retina.Current biology : CB · 2025Article
- Light Adaptation of Retinal Rod Bipolar Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.Physiological reports · 2018Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness.Human molecular genetics · 2015Article
- The Effect of PKCα on the Light Response of Rod Bipolar Cells in the Mouse Retina.Investigative ophthalmology & visual science · 2015Article
- GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Examination of VLC-PUFA-deficient photoreceptor terminals.Investigative ophthalmology & visual science · 2014Article
- A retinal ganglion cell that can signal irradiance continuously for 10 hours.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Light-induced plasticity of synaptic AMPA receptor composition in retinal ganglion cells.Neuron · 2012Article
- Characterization of Trpm1 desensitization in ON bipolar cells and its role in downstream signalling.The Journal of physiology · 2012Article
- Coordinated control of sensitivity by two splice variants of Gα(o) in retinal ON bipolar cells.The Journal of general physiology · 2010Article
- Calcium-induced calcium release contributes to synaptic release from mouse rod photoreceptors.Neuroscience · 2010Article
- Mechanisms underlying lateral GABAergic feedback onto rod bipolar cells in rat retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Inhibition of nitric oxide synthase desensitizes retinal ganglion cells to light by diminishing their excitatory synaptic currents under light adaptation.Vision research · 2009Article
- Switching between transient and sustained signalling at the rod bipolar-AII amacrine cell synapse of the mouse retina.The Journal of physiology · 2009Article
- A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa.The European journal of neuroscience · 2009Article
- Coagonist release modulates NMDA receptor subtype contributions at synaptic inputs to retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Light depolarizes retinal On bipolar cells, opening the cation-selective channels that are responsible for producing the synaptic current. In this study, the basic features of light-induced signals were mimicked by bathing slices of salamander retina with an agonist for the mGluR6 receptor that is expressed on the dendrites of On cells, and then displacing the agonist with the mGluR6 antagonist (RS)-a-cyclopropyl-4-phosphonophenylglycine (CPPG). The transduction current that is activated by this protocol rapidly shuts off, or desensitizes. Desensitization was highly correlated with the concentration and the type of Ca2+ buffer that was dialysed into the cell: When Ca2+ buffering was minimized by dialysing cells with 0.5 mM EGTA, the steady-state response was reduced to approximately 40% of the peak response. Buffering with 10 mM EGTA reduced desensitization, while BAPTA completely eliminated it. Removing external Ca2+ also prevented desensitization, suggesting that entry of Ca2+ through the transduction channel provides the trigger. The time course of desensitization was measured by using a voltage jump protocol to rapidly increase Ca2+ influx, and could be fitted with a single time constant on the order of 1 s, in good agreement with previously published rates of desensitization to steps of light in this species. It is proposed that Ca(2+)-dependent shut-off of the On bipolar cell transduction current may contribute to the conversion of sustained to transient light responses that predominate in the inner retina.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.