ArticleThe Journal of physiology2004
The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
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Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it, 263 citations in OpenAlex.
- Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review.Frontiers in genetics · 2019Pooled it
- Stimulus temperature modulates the psychophysical dimensions of salt taste.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Review
- Sodium Reduction Through Sensory Interactions With NaCl: Strategies and Underlying Mechanisms.Food science & nutrition · 2025Review
- Receptors and signaling for sour and salty: the ionic taste qualities.Chemical senses · 2025Review
- Differential Effect of TRPV1 Modulators on Neural and Behavioral Responses to Taste Stimuli.Nutrients · 2024Review
- The Expression of Cannabinoid and Cannabinoid-Related Receptors on the Gustatory Cells of the Piglet Tongue.Molecules (Basel, Switzerland) · 2024Article
- The complexities of salt taste reception: insights into the role of TMC4 in chloride taste detection.Frontiers in molecular neuroscience · 2024Review
- Pungency Perception and the Interaction with Basic Taste Sensations: An Overview.Foods (Basel, Switzerland) · 2023Review
- More spice, less salt: how capsaicin affects liking for and perceived saltiness of foods in people with smell loss.medRxiv : the preprint server for health sciences · 2023Article
- Salt Taste and Salt Sensitive Hypertension in HIV.Current hypertension reports · 2023Review
- A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation.Temperature (Austin, Tex.) · 2023Review
- Analysis of the rat chorda tympani nerve response to "super salty" sodium carbonate.Chemical senses · 2023Article
- Genetic variants in taste genes play a role in oral microbial composition and severe early childhood caries.iScience · 2022Article
- Molecular logic of salt taste reception in special reference to transmembrane channel-like 4 (TMC4).The journal of physiological sciences : JPS · 2022Review
- Relationship between ENaC Regulators and SARS-CoV-2 Virus Receptor (ACE2) Expression in Cultured Adult Human Fungiform (HBO) Taste Cells.Nutrients · 2022Article
- The impact of excessive salt intake on human health.Nature reviews. Nephrology · 2022Review
- Associations between chronic cigarette smoking and taste function: Results from the 2013-2014 national health and nutrition examination survey.Physiology & behavior · 2021Article
- Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1.International journal of molecular sciences · 2021Review
- Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes.Evolutionary bioinformatics online · 2021Article
50 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The amiloride-insensitive salt taste receptor is the predominant transducer of salt taste in some mammalian species, including humans. The physiological, pharmacological and biochemical properties of the amiloride-insensitive salt taste receptor were investigated by RT-PCR, by the measurement of unilateral apical Na+ fluxes in polarized rat fungiform taste receptor cells and by chorda tympani taste nerve recordings. The chorda tympani responses to NaCl, KCl, NH4Cl and CaCl2 were recorded in Sprague-Dawley rats, and in wild-type and vanilloid receptor-1 (VR-1) knockout mice. The chorda tympani responses to mineral salts were monitored in the presence of vanilloids (resiniferatoxin and capsaicin), VR-1 antagonists (capsazepine and SB-366791), and at elevated temperatures. The results indicate that the amiloride-insensitive salt taste receptor is a constitutively active non-selective cation channel derived from the VR-1 gene. It accounts for all of the amiloride-insensitive chorda tympani taste nerve response to Na+ salts and part of the response to K+, NH4+ and Ca2+ salts. It is activated by vanilloids and temperature (> 38 degrees C), and is inhibited by VR-1 antagonists. In the presence of vanilloids, external pH and ATP lower the temperature threshold of the channel. This allows for increased salt taste sensitivity without an increase in temperature. VR-1 knockout mice demonstrate no functional amiloride-insensitive salt taste receptor and no salt taste sensitivity to vanilloids and temperature. We conclude that the mammalian non-specific salt taste receptor is a VR-1 variant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.