ArticleMolecular and cellular biology2004
Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 110 citations in OpenAlex.
- Article
- Leishmania mexicana telomeres at high resolution: Ku80, TERT, and alternative lengthening mechanisms.BMC genomics · 2025Article
- Telomeres control human telomerase (eLife · 2025Article
- DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci.bioRxiv : the preprint server for biology · 2025Article
- LAP2α orchestrates alternative lengthening of telomeres suppression through telomeric heterochromatin regulation with HDAC1: unveiling a potential therapeutic target.Cell death & disease · 2024Article
- Noncanonical functions of Ku may underlie essentiality in human cells.Scientific reports · 2023Article
- Therapeutic Targeting of DNA Damage Response in Cancer.International journal of molecular sciences · 2022Review
- In Silico Design, Synthesis, and Biological Evaluation of Anticancer Arylsulfonamide Endowed with Anti-Telomerase Activity.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Review
- EXO1 resection at G-quadruplex structures facilitates resolution and replication.Nucleic acids research · 2020Article
- DNA-dependent protein kinase in telomere maintenance and protection.Cellular & molecular biology letters · 2020Review
- Transient introduction of human telomerase mRNA improves hallmarks of progeria cells.Aging cell · 2019Article
- Heregulin, a new regulator of telomere length in human cells.Oncotarget · 2015Article
- Deletion of the DNA Ligase IV Gene in Candida glabrata Significantly Increases Gene-Targeting Efficiency.Eukaryotic cell · 2015Article
- Getting down to the core of histone modifications.Chromosoma · 2014Review
- Article
- Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology.Advances in experimental medicine and biology · 2014Review
- PRKDC mutations in a SCID patient with profound neurological abnormalities.The Journal of clinical investigation · 2013Article
- Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction.Nucleic acids research · 2013Article
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Ku86 plays a key role in nonhomologous end joining in organisms as evolutionarily disparate as bacteria and humans. In eukaryotic cells, Ku86 has also been implicated in the regulation of telomere length although the effect of Ku86 mutations varies considerably between species. Indeed, telomeres either shorten significantly, shorten slightly, remain unchanged, or lengthen significantly in budding yeast, fission yeast, chicken cells, or plants, respectively, that are null for Ku86 expression. Thus, it has been unclear which model system is most relevant for humans. We demonstrate here that the functional inactivation of even a single allele of Ku86 in human somatic cells results in profound telomere loss, which is accompanied by an increase in chromosomal fusions, translocations, and genomic instability. Together, these experiments demonstrate that Ku86, separate from its role in nonhomologous end joining, performs the additional function in human somatic cells of suppressing genomic instability through the regulation of telomere length.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.