ArticleMolecular and cellular biology2004
Parent-of-origin-specific binding of nuclear hormone receptor complexes in the H19-Igf2 imprinting control region.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice.Epigenetics & chromatin · 2018Article
- Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Human molecular genetics · 2014Article
- Imprinting genes associated with endometriosis.EXCLI journal · 2014Review
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- Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites.PloS one · 2010Article
- A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells.Molecular and cellular biology · 2009Article
- Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer tracking.Human molecular genetics · 2008Article
- Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis.Reproductive toxicology (Elmsford, N.Y.) · 2008Article
- Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development.Development (Cambridge, England) · 2008Article
- Fine tuning of globin gene expression by DNA methylation.PloS one · 2006Article
- Genomic imprinting recapitulated in the human beta-globin locus.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region.Molecular and cellular biology · 2005Article
- Role of CTCF binding sites in the Igf2/H19 imprinting control region.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Parent-of-origin-specific expression of the mouse insulin-like growth factor 2 gene (Igf2) and the closely linked H19 gene located on distal chromosome 7 is regulated by a 2.4-kb imprinting control region (ICR) located upstream of the H19 gene. In somatic cells, the maternally and paternally derived ICRs are hypo- and hypermethylated, respectively, with the former binding the insulator protein CCCTC-binding factor (CTCF) and acting to block access of enhancers to the Igf2 promoter. Here we report on a detailed in vivo footprinting analysis-using ligation-mediated PCR combined with in vivo dimethyl sulfate, DNase I, or UV treatment-of ICR sequences located outside of the CTCF binding domains. In mouse primary embryo fibroblasts carrying only maternal or paternal copies of distal chromosome 7, we have identified five prominent footprints specific to the maternal ICR. Each of the five footprinted areas contains at least two nuclear hormone receptor hexad binding sites arranged with irregular spacing. When combined with fibroblast nuclear extracts, these sequences interact with complexes containing retinoic X receptor alpha and estrogen receptor beta. More significantly, the footprint sequences bind nuclear hormone receptor complexes in male, but not female, germ cell extracts purified from fetuses at a developmental stage corresponding to the time of establishment of differential ICR methylation. These data are consistent with the possibility that nuclear hormone receptor complexes participate in the establishment of differential ICR methylation imprinting in the germ line.
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