ArticleMolecular and cellular biology2004
Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development.Nature communications · 2023Article
- The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis.Cells · 2023Article
- Nuclear TransporterCells · 2022Article
- Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD.Brain sciences · 2021Article
- Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response.Nature communications · 2021Article
- Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration.International journal of molecular sciences · 2021Review
- The genetic architecture of aniridia and Gillespie syndrome.Human genetics · 2019Review
- Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.PloS one · 2016Article
- The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.PloS one · 2015Article
- Nuclear import of aristaless-related homeobox protein via its NLS1 regulates its transcriptional function.Molecular and cellular biochemistry · 2013Article
- Expression and subcellular distribution of imp13 are regulated in brain development.In vitro cellular & developmental biology. Animal · 2013Article
- Structural basis for the nuclear export activity of Importin13.The EMBO journal · 2013Article
- Increased importin 13 activity is associated with the pathogenesis of pterygium.Molecular vision · 2013Article
- Karyopherins in nuclear transport of homeodomain proteins during development.Biochimica et biophysica acta · 2011Review
- Nuclear import by karyopherin-βs: recognition and inhibition.Biochimica et biophysica acta · 2011Review
- Evolution of the karyopherin-β family of nucleocytoplasmic transport factors; ancient origins and continued specialization.PloS one · 2011Article
- Article
- A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH.Molecular and cellular biochemistry · 2009Article
- Importin 13 serves as a potential marker for corneal epithelial progenitor cells.Stem cells (Dayton, Ohio) · 2009Article
- The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein.The Journal of biological chemistry · 2009Article
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Authors and funding
3 authors.
Funding
Abstract
We report that the paired homeodomain transcription factor Pax6 is imported into the nucleus by the Karyopherin beta family member Karyopherin 13 (Kap13). Pax6 was identified as a potential cargo for Kap13 by a yeast two-hybrid screen. Direct binding of Pax6 to Kap13 was subsequently confirmed by in vitro assays with recombinant proteins, and binding in vivo was shown by coimmunoprecipitation. Ran-dependent import of Pax6 by Kap13 was shown to occur by using a digitonin-permeabilized cells assay. Kap13 binds to Pax6 via a nuclear localization sequence (NLS), which is located within a segment of 80 amino acid residues that includes the homeodomain. Kap13 showed reduced binding to Pax6 when either region located at each end of the homeodomain (208 to 214 and 261 to 267) was deleted. The paired-type homeodomain transcription factor family includes more than 20 members. All members contain a region similar to the NLS found in Pax6 and are therefore likely to be imported by Kap13. We confirmed this hypothesis for Pax3 and Crx, which bind to and are imported by Kap13.
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