ArticleMolecular and cellular biology2004
Bromodomain factor 1 (Bdf1) is phosphorylated by protein kinase CK2.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The extra-terminal domain drives the role of BET proteins in transcription.Nucleic acids research · 2026Article
- Viral Hijacking of BET Proteins.Viruses · 2022Review
- Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins.Communications biology · 2021Article
- Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Genome-wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis.Molecular reproduction and development · 2021Article
- Article
- Signaling coupled epigenomic regulation of gene expression.Oncogene · 2017Review
- HAL2 overexpression induces iron acquisition in bdf1Δ cells and enhances their salt resistance.Current genetics · 2017Article
- Why are essential genes essential? - The essentiality ofMicrobial cell (Graz, Austria) · 2015Review
- The yeast BDF1 regulates endocytosis via LSP1 under salt stress.Current microbiology · 2015Article
- Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism.PLoS computational biology · 2015Article
- RNA-Seq analysis identifies a novel set of editing substrates for human ADAR2 present in Saccharomyces cerevisiae.Biochemistry · 2013Article
- Casein kinase 2 associates with the yeast chromatin reassembly factor Spt2/Sin1 to regulate its function in the repression of spurious transcription.Molecular and cellular biology · 2013Article
- Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting.Molecular cell · 2013Article
- Article
- Peptoid ligands that bind selectively to phosphoproteins.Bioorganic & medicinal chemistry letters · 2011Article
- Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast.RNA (New York, N.Y.) · 2011Article
- Article
- Genetic and comparative transcriptome analysis of bromodomain factor 1 in the salt stress response of Saccharomyces cerevisiae.Current microbiology · 2007Article
- Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae.Molecular and cellular biology · 2005Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Bromodomain factor 1 (Bdf1) associates with Saccharomyces cerevisiae TFIID and corresponds to the C-terminal half of higher eukaryotic TAF1. It also associates with the SWR-C complex, which is important for Htz1 deposition. Bdf1 binds preferentially to acetylated histone H4. Bdf1 is phosphorylated, but the mechanism and significance of this modification have been unclear. Two distinct regions within Bdf1 are phosphorylated; one is just C terminal to the bromodomains and the other is near the C terminus. Mutational analysis shows that phosphorylation is necessary for Bdf1 function in vivo. Endogenous protein kinase CK2 purifies with Bdf1 and phosphorylates both domains. A similar mechanism may be responsible for phosphorylation of the C-terminal region of mammalian TAF1. These findings suggest that CK2 phosphorylation of Bdf1 may regulate RNA polymerase II transcription and/or chromatin structure.
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