Trial reportBMJ (Clinical research ed.)2004
Effects of transfusion with red cells filtered to remove leucocytes: randomised controlled trial in patients undergoing major surgery.
Trial report in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Leukoreduction for the prevention of adverse reactions from allogeneic blood transfusion.The Cochrane database of systematic reviews · 2015Pooled it
- Red cell transfusion management for patients undergoing cardiac surgery for congenital heart disease.The Cochrane database of systematic reviews · 2014Pooled it
- Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study.Critical care (London, England) · 2014Trial
- Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study.Critical care (London, England) · 2011Trial
- The effect of the leukoreduction filtration moment on the clinical outcome of transfused patients: A retrospective cohort study.Clinics (Sao Paulo, Brazil) · 2025Article
- Effect of perioperative blood transfusion on complications and prognosis after radical gastrectomy in elderly patients: a retrospective study of 1,666 cases.Journal of gastrointestinal oncology · 2024Article
- Mismatch of populations between randomised controlled trials of perioperative interventions in major abdominal surgery and current clinical practice.Perioperative medicine (London, England) · 2023Review
- Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer.World journal of gastroenterology · 2019Review
- Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis.Cardiology research and practice · 2019Review
- Effect of storage period of red blood cell suspensions on helper T-cell subpopulations.Blood transfusion = Trasfusione del sangue · 2018Article
- Comment on Debate: Blood is Friend or/and Foe?Turkish journal of anaesthesiology and reanimation · 2018Article
- Metabolic effects occurring in irradiated and non-irradiated red blood cellular components for clinical transfusion practice: An in vitro comparison.African journal of laboratory medicine · 2018Article
- Blood Transfusions Correct Anemia and Improve Tissue Oxygenation in Surgical and Critically ill Patients.Turkish journal of anaesthesiology and reanimation · 2017Article
- Leucoreduction of blood components: an effective way to increase blood safety?Blood transfusion = Trasfusione del sangue · 2016Review
- Adverse prognostic impact of perioperative allogeneic transfusion on patients with stage II/III gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro.Transfusion · 2014Article
- The abandoned controversy surrounding universal white blood cell reduction.Blood transfusion = Trasfusione del sangue · 2014Article
- Cost-effectiveness of leucoreduction for prevention of febrile non-haemolytic transfusion reactions.Blood transfusion = Trasfusione del sangue · 2014Article
- Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions.British journal of anaesthesia · 2013Review
- Transfusion immunomodulation--the case for leukoreduced and (perhaps) washed transfusions.Blood cells, molecules & diseases · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare postoperative complications in patients undergoing major surgery who received non-filtered or filtered red blood cell transfusions.
designProspective, randomised, double blinded trial.
setting19 hospitals throughout the Netherlands (three university; 10 clinical; six general).
participants1051 evaluable patients: 79 patients with ruptured aneurysm, 412 patients undergoing elective surgery for aneurysm, and 560 undergoing gastrointestinal surgery.
interventionsThe non-filtered products had the buffy coat removed and were plasma reduced. The filtered products had the buffy coat removed, were plasma reduced, and filtered before storage to remove leucocytes.
main outcome measuresMortality and duration of stay in intensive care. Secondary end points were occurrence of multi-organ failure, infections, and length of hospital stay.
resultsNo significant differences were found in mortality (odds ratio for filtered v non-filtered 0.80, 95% confidence interval 0.53 to 1.21) and in mean stay in intensive care (- 0.4 day, - 1.6 to 0.6 day). In the filtered group the mean length of hospital stay was 2.4 days shorter (- 4.8 to 0.0 day; P = 0.050) and the incidence of multi-organ failure was 30% lower (odds ratio 0.70, 0.49 to 1.00; P = 0.050). There were no differences in rates of infection (0.98, 0.73 to 1.32).
conclusionThe use of filtered transfusions in some types of major surgery may reduce the length of hospital stay and the incidence of postoperative multi-organ failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.