ArticleArthritis research & therapy2004
Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice.
Article in Arthritis research & therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
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- Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?International journal of molecular sciences · 2022Review
- miR-34a overexpression protects against hippocampal neuron damage caused by ketamine-induced anesthesia in immature rats through the Notch-1/NF-κB signaling pathway.American journal of translational research · 2021Article
- Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis.Frontiers in pharmacology · 2020Article
- The Impact of Dietary Components on Regulatory T Cells and Disease.Frontiers in immunology · 2020Review
- Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis.Mediators of inflammation · 2016Article
- Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.The Journal of pharmacology and experimental therapeutics · 2015Article
- Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells.PloS one · 2014Article
- Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.Autoimmunity · 2011Article
- IL-17 in obesity and adipogenesis.Cytokine & growth factor reviews · 2010Review
- Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy.Journal of perinatal medicine · 2010Article
- Retinol binding protein 4--a novel association with early-onset preeclampsia.Journal of perinatal medicine · 2010Article
- The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Article
- Retinol binding protein 4: an adipokine associated with intra-amniotic infection/inflammation.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2010Article
- Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection.Journal of perinatal medicine · 2010Article
- Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.Journal of leukocyte biology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The severity of antigen-induced arthritis (AIA) is decreased in leptin-deficient ob/ob mice. However, joint inflammation in AIA depends on the immune response, which is impaired in ob/ob mice. In the present study we investigated the effects of leptin deficiency on zymosan-induced arthritis (ZIA), which is independent of adaptive immunity. Arthritis was induced by injection of zymosan into the knee joint. Joint swelling was similar after 6 and 24 hours in ob/ob and control mice. However, it remained elevated in ob/ob animals on day 3 whereas values normalized in controls. Histology revealed similar articular lesions in all animals on day 3, but on days 14 and 21 arthritis tended to be more severe in ob/ob mice. The acute phase response, reflected by circulating levels of IL-6 and serum amyloid A, was also more pronounced in ob/ob mice, although corticosterone was significantly elevated in these animals. Similar results were obtained in leptin receptor-deficient db/db mice. Thus, in contrast to AIA, ZIA is not impaired in leptin-deficient animals. On the contrary, resolution of acute inflammation appears to be delayed in the absence of leptin or leptin signalling, suggesting that chronic leptin deficiency interferes with adequate control of the inflammatory response in ZIA.
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