Evidence map›Paper›PMID 15141336›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2004

In vitro activity of amphotericin B, fluconazole and voriconazole against 162 Cryptococcus neoformans isolates from Africa and Cambodia.

J Chandenier, K D Adou-Bryn, C Douchet, B Sar, M Kombila, D Swinne, M Thérizol-Ferly, Y Buisson, D Richard-Lenoble

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Antifungal Resistance in Cryptococcal Infections.Pathogens (Basel, Switzerland) · 2024
    Review
  3. Cryptococcus neoformans, a global threat to human health.Infectious diseases of poverty · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Infection and drug resistance · 2020
    Article
  8. Article
  9. Review
  10. Article
  11. Microbiological characteristics of clinical isolates of Cryptococcus spp. in Bahia, Brazil: molecular types and antifungal susceptibilities.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Voriconazole in the management of nosocomial invasive fungal infections.Therapeutics and clinical risk management · 2006
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J ChandenierService de Parasitologie-Mycologie-Médecine Tropicale, Centre Hospitalier et Universitaire, 37000 Tours, France. jac-bri.chandenier@wanadoo.fr
K D Adou-Bryn
C Douchet
B Sar
M Kombila
D Swinne
M Thérizol-Ferly
Y Buisson
D Richard-Lenoble

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to determine the potential role that various antifungal agents might have in the management of cryptococcosis in tropical areas, the in vitro susceptibility of Cryptococcus neoformans isolates from Africa ( n=52) and Cambodia ( n=110) to three antifungal agents (amphotericin B, fluconazole and voriconazole) were compared using the E-test method. The results of this study (i) confirm the value of the E-test for testing the in vitro susceptibility of C. neoformans towards voriconazole; (ii) provide the first evidence demonstrating good activity of amphotericin B, fluconazole and voriconazole against Cambodian isolates; and (iii) show there are differences in susceptibility between African and Asian C. neoformans isolates, with Cambodian isolates appearing less susceptible to the agents tested but with amphotericin B maintaining good activity.

Indexed as

AfricaAmphotericin BAntifungal AgentsCambodiaCryptococcosisCryptococcus neoformansDeveloping CountriesDrug Resistance, FungalFemaleFluconazoleHumansMaleMicrobial Sensitivity TestsPyrimidinesRisk AssessmentSampling StudiesAmphotericin BAntifungal AgentsFluconazolePyrimidinesTriazolesVoriconazole

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.