ArticleThe EMBO journal2004
Talin B is required for force transmission in morphogenesis of Dictyostelium.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
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- A Microfluidic Design for Quantitative Measurements of Shear Stress-Dependent Adhesion and Motion ofBiomimetics (Basel, Switzerland) · 2024Article
- The Low-Abundance Plasma Proteome Reveals Differentially Abundant Proteins Associated with Breast Implant Capsular Contracture: A Pilot Study.Proteomes · 2024Article
- Differential venom gland gene expression analysis of juvenile and adult scorpions Androctonus crassicauda.BMC genomics · 2022Article
- Adhesion ofFrontiers in cell and developmental biology · 2022Review
- AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment.Frontiers in molecular biosciences · 2022Article
- An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration.Frontiers in cell and developmental biology · 2022Review
- Gradients of PI(4,5)PFrontiers in cell and developmental biology · 2022Article
- Talin2 regulates invasion of human breast cancer MDA-MB-231 cells via alteration of the tumor microenvironment.Oncology letters · 2019Article
- Article
- Talin2 regulates breast cancer cell migration and invasion by apoptosis.Oncology letters · 2018Article
- The tale of two talins - two isoforms to fine-tune integrin signalling.FEBS letters · 2018Review
- Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons fromInterface focus · 2016Review
- Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.BMC cancer · 2016Article
- Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells.BMC cell biology · 2016Article
- The adhesion modulation protein, AmpA localizes to an endocytic compartment and influences substrate adhesion, actin polymerization and endocytosis in vegetative Dictyostelium cells.BMC cell biology · 2012Article
- Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.Molecular and cellular biology · 2011Article
- Stretching actin filaments within cells enhances their affinity for the myosin II motor domain.PloS one · 2011Article
- Evolution of complexity in the integrin adhesome.The Journal of cell biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Talin plays a key role in the assembly and stabilisation of focal adhesions, but whether it is directly involved in force transmission during morphogenesis remains to be elucidated. We show that the traction force of Dictyostelium cells mutant for one of its two talin genes talB is considerably smaller than that of wild-type cells, both in isolation and within tissues undergoing morphogenetic movement. The motility of mutant cells in tightly packed tissues in vivo or under strong resistance conditions in vitro was lower than that of wild-type cells, but their motility under low external force conditions was not impaired, indicating inefficient transmission of force in mutant cells. Antibody staining revealed that the talB gene product (talin B) exists as small units subjacent to the cell membrane at adhesion sites without forming large focal adhesion-like assemblies. The total amount of talin B on the cell membrane was larger in prestalk cells, which exert larger force than prespore cells during morphogenesis. We conclude that talin B is involved in force transmission between the cytoskeleton and cell exterior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.