Apoptin/VP3 contains a concentration-dependent nuclear localization signal (NLS), not a tumorigenic selective NLS.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Apoptin as a Tumor-Specific Therapeutic Agent: Current Perspective on Mechanism of Action and Delivery Systems.Frontiers in cell and developmental biology · 2020
   Review
2. Enhanced tumour cell nuclear targeting in a tumour progression model.BMC cancer · 2015
   Article
3. Mechanisms of Apoptin-induced cell death.Medical oncology (Northwood, London, England) · 2012
   Review
4. Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.Journal of virology · 2006
   Article
5. Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent.Oncogene · 2006
   Article
6. Apoptin: specific killer of tumor cells?Apoptosis : an international journal on programmed cell death · 2005
   Review
7. Apoptin induces chromatin condensation in normal cells.Virus genes · 2005
   Article
8. A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin.Journal of virology · 2005
   Article
9. Relevance of apoptin's integrity for its functional behavior.Journal of virology · 2005
   Article

Corrections and comments

• Commented on by
  Relevance of apoptin's integrity for its functional behavior.2005
• Commented on by
  A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin.2005

Authors and funding

4 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as