Evidence map›Paper›PMID 15141005›Full record

ArticleJournal of virology2004

Reverse genetic analysis of the transcription regulatory sequence of the coronavirus transmissible gastroenteritis virus.

Kristopher M Curtis, Boyd Yount, Amy C Sims, Ralph S Baric

Abstract read
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. The molecular biology of coronaviruses.Advances in virus research · 2006
    Review
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kristopher M CurtisDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435, USA. rbaric@email.unc.edu
Boyd Yount
Amy C Sims
Ralph S Baric

Funding

STUDIES INTO THE MECHANISMS FOR MHV REPLICATIONR01AI023946 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 1986 to 2007
$2.3M
REVERSE GENETICS WITH A CORONAVIRUS INFECTIOUS CONSTRUCTR01GM063228 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 2001 to 2004
$1.0M
NIAID NIH HHS AI23946NIAID NIH HHS R01 AI023946NIGMS NIH HHS GM63228NIGMS NIH HHS R01 GM063228
6 · The paper itself

Abstract

Coronavirus discontinuous transcription uses a highly conserved sequence (CS) in the joining of leader and body RNAs. Using a full-length infectious construct of transmissable gastroenteritis virus, the present study demonstrates that subgenomic transcription is heavily influenced by upstream flanking sequences and supports a mechanism of transcription attenuation that is regulated in part by a larger domain composed of primarily upstream flanking sequences which select appropriately positioned CS elements for synthesis of subgenomic RNAs.

Indexed as

Regulatory Sequences, Nucleic AcidTranscription, GeneticBase SequenceConserved SequenceMolecular Sequence DataOpen Reading FramesRecombination, GeneticTransmissible gastroenteritis virus

Identifiers

PMID15141005
PMCPMC415797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.