ArticleJournal of virology2004
Density-dependent selection in vesicular stomatitis virus.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Heterogeneity in viral populations increases the rate of deleterious mutation accumulation.Genetics · 2022Article
- Viral Aggregation: The Knowns and Unknowns.Viruses · 2022Review
- Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome.PLoS pathogens · 2021Article
- Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression.Royal Society open science · 2021Article
- Collective interactions augment influenza A virus replication in a host-dependent manner.Nature microbiology · 2020Article
- Natural selection in compartmentalized environment with reshuffling.Journal of mathematical biology · 2019Article
- Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.Annual review of virology · 2018Review
- Beneficial coinfection can promote within-host viral diversity.Virus evolution · 2018Article
- Improving virus production through quasispecies genomic selection and molecular breeding.Scientific reports · 2016Article
- Antigenic diversification is correlated with increased thermostability in a mammalian virus.Virology · 2016Article
- The fitness effects of a point mutation in Escherichia coli change with founding population density.Genetica · 2016Article
- Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units.Cell host & microbe · 2015Article
- The Multiplicity of Cellular Infection Changes Depending on the Route of Cell Infection in a Plant Virus.Journal of virology · 2015Article
- Genome rearrangement affects RNA virus adaptability on prostate cancer cells.Frontiers in genetics · 2015Article
- Congruent evolution of fitness and genetic robustness in vesicular stomatitis virus.Journal of virology · 2013Article
- The role of environmental factors on the evolution of phenotypic diversity in vesicular stomatitis virus populations.The Journal of general virology · 2013Article
- Article
- Evolutionary dynamics of genome segmentation in multipartite viruses.Proceedings. Biological sciences · 2012Article
- Competition-colonization trade-off promotes coexistence of low-virulence viral strains.Journal of the Royal Society, Interface · 2012Article
- Viral population dynamics and virulence thresholds.Current opinion in microbiology · 2012Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
We used vesicular stomatitis virus to test the effect of complementation on the relative fitness of a deleterious mutant, monoclonal antibody-resistant mutant (MARM) N, in competition with its wild-type ancestor. We carried out competitions of MARM N and wild-type populations at different multiplicities of infection (MOIs) and initial ratios of the wild type to the mutant and found that the fitness of MARM N relative to that of the wild type is very sensitive to changes in the MOI (i.e., the degree of complementation) but depends little, if at all, on the initial frequencies of MARM N and the wild type. Further, we developed a mathematical model under the assumption that during coinfection both viruses contribute to a common pool of protein products in the infected cell and that they both exploit this common pool equally. Under such conditions, the fitness of all virions that coinfect a cell is the average fitness in the absence of coinfection of that group of virions. In the absence of coinfection, complementation cannot take place and the relative fitness of each competitor is only determined by the selective value of its own products. We found good agreement between our experimental results and the model predictions, which suggests that the wild type and MARM N freely share all of their gene products under coinfection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.