ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
The function of neurotrophic factor receptors expressed by the developing adductor motor pool in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
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- Progress in spinal cord organoid research: advancing understanding of neural development, disease modelling, and regenerative medicine.Biomaterials translational · 2024Review
- Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.Cell reports · 2016Article
- Synergic effects of EPI-NCSCs and OECs on the donor cells migration, the expression of neurotrophic factors, and locomotor recovery of contused spinal cord of rats.Journal of molecular neuroscience : MN · 2015Article
- α2-chimaerin is required for Eph receptor-class-specific spinal motor axon guidance and coordinate activation of antagonistic muscles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Motor neurons and the generation of spinal motor neuron diversity.Frontiers in cellular neuroscience · 2014Review
- Motoneuron programmed cell death in response to proBDNF.Developmental neurobiology · 2012Article
- Pool-specific regulation of motor neuron survival by neurotrophic support.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Motor neuron trophic factors: therapeutic use in ALS?Brain research reviews · 2011Review
- Conditional, genetic disruption of ciliary neurotrophic factor receptors reveals a role in adult motor neuron survival.The European journal of neuroscience · 2008Article
- The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS.Journal of neurobiology · 2006Article
- Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system.The Journal of comparative neurology · 2006Article
- Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Extracellular heat shock protein 70: a critical component for motoneuron survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Phosphorylation of c-Jun in avian and mammalian motoneurons in vivo during programmed cell death: an early reversible event in the apoptotic cascade.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We examined the spatio-temporal relationship between neurotrophic factor receptor (NTF-R) expression and motoneuron (MN) survival in the developing avian spinal cord and observed heterogeneity in the expression of NTF-Rs between, but not within, pools of MNs projecting to individual muscles. We then focused on the role of NTFs in regulating the survival of one motor pool of MNs, all of which innervate a pair of adductor muscles in the thigh and hence compete for survival during the period of programmed cell death (PCD). The complete NTF-R complement of these MNs was analyzed and found to include many, but not all, NTF-Rs. Treatment with exogenous individual NTFs rescued some, but not all, adductor MNs expressing appropriate NTF-Rs. In contrast, administration of multiple NTFs completely rescued adductor MNs from PCD. Additionally, adductor MNs were partially rescued from PCD by NTFs for which they failed to express receptors. NTF-Rs expressed by the nerve but not in the muscle target were capable of mediating survival signals to MNs in trans. Finally, the expression of some NTF-Rs by adductor MNs was not required for MN survival. These studies demonstrate the complexity in NTF regulation of a defined subset of competing MNs and suggest that properties other than NTF-R expression itself can play a role in mediating trophic responses to NTFs.
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