ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy · 2016Guideline
- Guideline
- Taming the "death receptor": translating the first-in-class p75Journal of translational medicine · 2026Review
- Small molecule modulation of p75Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development.Frontiers in molecular neuroscience · 2023Review
- Review
- Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis.International journal of molecular sciences · 2021Review
- Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders.Frontiers in cellular neuroscience · 2020Review
- Multiple pathways for mitophagy: A neurodegenerative conundrum for Parkinson's disease.Neuroscience letters · 2019Review
- Opposite Expression Patterns ofFrontiers in psychiatry · 2019Article
- Deciphering the Role Played by Autophagy inFrontiers in immunology · 2019Review
- Article
- Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse.International journal of molecular sciences · 2016Article
- Role of autophagy in the pathogenesis of multiple sclerosis.Neuroscience bulletin · 2015Article
- SUMO1 promotes Aβ production via the modulation of autophagy.Autophagy · 2015Article
- Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1.Journal of experimental neuroscience · 2015Review
- Aβ selectively impairs mGluR7 modulation of NMDA signaling in basal forebrain cholinergic neurons: implication in Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.Membranes · 2014Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The cellular mechanisms underlying Purkinje neuron death in various neurodegenerative disorders of the cerebellum are poorly understood. Here we investigate an in vitro model of cerebellar neuronal death. We report that cerebellar Purkinje neurons, deprived of trophic factors, die by a form of programmed cell death distinct from the apoptotic death of neighboring granule neurons. Purkinje neuron death was characterized by excessive autophagic-lysosomal vacuolation. Autophagy and death of Purkinje neurons were inhibited by nerve growth factor (NGF) and were activated by NGF-neutralizing antibodies. Although treatment with antisense oligonucleotides to the p75 neurotrophin receptor (p75ntr) decreased basal survival of cultured cerebellar neurons, p75ntr-antisense decreased autophagy and completely inhibited death of Purkinje neurons induced by trophic factor withdrawal. Moreover, adenoviral expression of a p75ntr mutant lacking the ligand-binding domain induced vacuolation and death of Purkinje neurons. These results suggest that p75ntr is required for Purkinje neuron survival in the presence of trophic support; however, during trophic factor withdrawal, p75ntr contributes to Purkinje neuron autophagy and death. The autophagic morphology resembles that found in neurodegenerative disorders, suggesting a potential role for this pathway in neurological disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.