ArticleGenome research2004
Systems level insights into the stress response to UV radiation in the halophilic archaeon Halobacterium NRC-1.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed, 143 citations in OpenAlex.
- Life resists chemistry not conditions.FEMS microbes · 2026Article
- Investigation of the global translational response to oxidative stress in the model archaeonmSphere · 2025Article
- From freezing to functioning: cellular strategies of cold-adapted bacteria for surviving in extreme environments.Archives of microbiology · 2024Review
- HtrAs are essential for the survival of the haloarchaeonApplied and environmental microbiology · 2024Article
- The archaeal classFrontiers in microbiology · 2022Article
- Molecular acclimation ofFrontiers in microbiology · 2022Article
- Post-transcriptional regulation of redox homeostasis by the small RNA SHOxi in haloarchaea.RNA biology · 2021Article
- Experimental evolution of extremophile resistance to ionizing radiation.Trends in genetics : TIG · 2021Review
- Review
- The Role of Stress Proteins in Haloarchaea and Their Adaptive Response to Environmental Shifts.Biomolecules · 2020Review
- Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing.PloS one · 2020Article
- Life in High Salt Concentrations with Changing Environmental Conditions: Insights from Genomic and Phenotypic Analysis ofMicroorganisms · 2019Article
- The Primary Antisense Transcriptome ofGenes · 2019Article
- Increase of positive supercoiling in a hyperthermophilic archaeon after UV irradiation.Extremophiles : life under extreme conditions · 2019Article
- Copy number variation is associated with gene expression change in archaea.Microbial genomics · 2018Article
- An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea.Nucleic acids research · 2018Article
- The Rab GTPase activating protein Gyp2 contributes to UV stress tolerance in Metarhizium acridum.World journal of microbiology & biotechnology · 2018Article
- Halobacterium salinarum storage and rehydration after spray drying and optimization of the processes for preservation of carotenoids.Extremophiles : life under extreme conditions · 2018Article
- Microbial radiation-resistance mechanisms.Journal of microbiology (Seoul, Korea) · 2017Review
- Mechanism for microbial population collapse in a fluctuating resource environment.Molecular systems biology · 2017Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
We report a remarkably high UV-radiation resistance in the extremely halophilic archaeon Halobacterium NRC-1 withstanding up to 110 J/m2 with no loss of viability. Gene knockout analysis in two putative photolyase-like genes (phr1 and phr2) implicated only phr2 in photoreactivation. The UV-response was further characterized by analyzing simultaneously, along with gene function and protein interactions inferred through comparative genomics approaches, mRNA changes for all 2400 genes during light and dark repair. In addition to photoreactivation, three other putative repair mechanisms were identified including d(CTAG) methylation-directed mismatch repair, four oxidative damage repair enzymes, and two proteases for eliminating damaged proteins. Moreover, a UV-induced down-regulation of many important metabolic functions was observed during light repair and seems to be a phenomenon shared by all three domains of life. The systems analysis has facilitated the assignment of putative functions to 26 of 33 key proteins in the UV response through sequence-based methods and/or similarities of their predicted three-dimensional structures to known structures in the PDB. Finally, the systems analysis has raised, through the integration of experimentally determined and computationally inferred data, many experimentally testable hypotheses that describe the metabolic and regulatory networks of Halobacterium NRC-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.