ArticleGenome research2004
Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.Ophthalmology · 2019Article
- Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping.European journal of human genetics : EJHG · 2014Article
- Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments.American journal of human genetics · 2012Article
- Human population admixture in Asia.Genomics & informatics · 2012Article
- Global prostate cancer incidence and the migration, settlement, and admixture history of the Northern Europeans.Cancer epidemiology · 2011Article
- Race as a social construct in head and neck cancer outcomes.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2011Article
- Detecting directional selection in the presence of recent admixture in African-Americans.Genetics · 2011Article
- Article
- Admixture mapping as a tool in gene discovery.Current opinion in genetics & development · 2007Review
- Argentine population genetic structure: large variance in Amerindian contribution.American journal of physical anthropology · 2007Article
- A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping.American journal of human genetics · 2006Article
- Reconstructing genetic ancestry blocks in admixed individuals.American journal of human genetics · 2006Article
- Clinical applications of Genome Polymorphism Scans.Biology direct · 2006Article
- Article
- Multiple sclerosis genetics: leaving no stone unturned.Genes and immunity · 2005Review
- Admixture mapping as a gene discovery approach for complex human traits and diseases.Current hypertension reports · 2005Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative ancestral origin was examined by using haplotypes estimated from genotyping 268 African Americans for 29 ancestry informative markers spaced over a 60-cM segment of chromosome 5. Analyses using a Bayesian algorithm (STRUCTURE) provided evidence that blocks of individual chromosomes derive from one or the other parental population. In addition, modeling studies were performed by using hidden real marker data to simulate patient and control populations under different genotypic risk ratios. Ancestry analysis showed significant results for a genotypic risk ratio of 2.5 in the African American population for modeled susceptibility genes derived from either putative parental population. These studies suggest that admixture mapping in the African American population can provide a powerful approach to defining genetic factors for some disease phenotypes.
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Registered trials
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